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- W4316014711 endingPage "122004" @default.
- W4316014711 startingPage "122004" @default.
- W4316014711 abstract "New antimicrobials are urgently needed to combat Gram-negative bacteria, particularly multi-drug resistant (MDR) and phenotypically resistant biofilm species. At present, only sequence-defined alpha-peptides (e.g. polymyxin B) can selectively target Gram-negative bacterial lipopolysaccharides. We show that a copolymer, without a defined sequence, shows good potency against MDR Gram-negative bacteria including its biofilm form. The tapered blocky co-beta-peptide with controlled N-terminal hydrophobicity (#4) has strong interaction with the Gram-negative bacterial lipopolysaccharides via its backbone through electrostatic and hydrogen bonding interactions but not the Gram-positive bacterial and mammalian cell membranes so that this copolymer is non-toxic to these two latter cell types. The new #4 co-beta-peptide selectively kills Gram-negative bacteria with low cytotoxicity both in vitro and in a mouse biofilm wound infection model. This strategy provides a new concept for the design of Gram-negative selective antimicrobial peptidomimetics against MDR and biofilm species." @default.
- W4316014711 created "2023-01-14" @default.
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- W4316014711 date "2023-03-01" @default.
- W4316014711 modified "2023-09-27" @default.
- W4316014711 title "Designer co-beta-peptide copolymer selectively targets resistant and biofilm Gram-negative bacteria" @default.
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- W4316014711 doi "https://doi.org/10.1016/j.biomaterials.2023.122004" @default.
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