Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319073852> ?p ?o ?g. }
- W4319073852 endingPage "102848" @default.
- W4319073852 startingPage "102848" @default.
- W4319073852 abstract "As nanocarriers (NCs) can improve the solubility of drugs, prevent their degradation by gastrointestinal (GI) enzymes and promote their transport across the mucus gel layer and absorption membrane, the oral bioavailability of these drugs can be substantially enhanced. All these properties of NCs including self-emulsifying drug delivery systems (SEDDS), solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), liposomes, polymeric nanoparticles, inorganic nanoparticles and polymeric micelles depend mainly on their surface chemistry. In particular, interaction with food, digestive enzymes, bile salts and electrolytes, diffusion behaviour across the mucus gel layer and fate on the absorption membrane are determined by their surface. Bioinert surfaces limiting interactions with gastrointestinal fluid and content as well as with mucus, adhesive surfaces providing an intimate contact with the GI mucosa and absorption enhancing surfaces can be designed. Furthermore, charge converting surfaces shifting their zeta potential from negative to positive directly at the absorption membrane and surfaces providing a targeted drug release are advantageous. In addition to these passive surfaces, even active surfaces cleaving mucus glycoproteins on their way through the mucus gel layer can be created. Within this review, we provide an overview on these different surfaces and discuss their impact on the performance of NCs in the GI tract." @default.
- W4319073852 created "2023-02-04" @default.
- W4319073852 creator A5003673893 @default.
- W4319073852 creator A5035632031 @default.
- W4319073852 creator A5037800020 @default.
- W4319073852 creator A5048438851 @default.
- W4319073852 date "2023-03-01" @default.
- W4319073852 modified "2023-10-16" @default.
- W4319073852 title "Surface design of nanocarriers: Key to more efficient oral drug delivery systems" @default.
- W4319073852 cites W148530083 @default.
- W4319073852 cites W1511118087 @default.
- W4319073852 cites W187610472 @default.
- W4319073852 cites W1963819255 @default.
- W4319073852 cites W1964872366 @default.
- W4319073852 cites W1974178315 @default.
- W4319073852 cites W1977692641 @default.
- W4319073852 cites W1980226233 @default.
- W4319073852 cites W1982552549 @default.
- W4319073852 cites W1983895469 @default.
- W4319073852 cites W1991252094 @default.
- W4319073852 cites W1991720510 @default.
- W4319073852 cites W1995616899 @default.
- W4319073852 cites W1999156535 @default.
- W4319073852 cites W2000302106 @default.
- W4319073852 cites W2001902661 @default.
- W4319073852 cites W2002380094 @default.
- W4319073852 cites W2002781860 @default.
- W4319073852 cites W2004330460 @default.
- W4319073852 cites W2005161126 @default.
- W4319073852 cites W2009805582 @default.
- W4319073852 cites W2010220086 @default.
- W4319073852 cites W2013399032 @default.
- W4319073852 cites W2014928486 @default.
- W4319073852 cites W2015530052 @default.
- W4319073852 cites W2017152614 @default.
- W4319073852 cites W2017739484 @default.
- W4319073852 cites W2018215694 @default.
- W4319073852 cites W2019764810 @default.
- W4319073852 cites W2022132405 @default.
- W4319073852 cites W2022877634 @default.
- W4319073852 cites W2024800994 @default.
- W4319073852 cites W2025182473 @default.
- W4319073852 cites W2029940588 @default.
- W4319073852 cites W2033569715 @default.
- W4319073852 cites W2033857478 @default.
- W4319073852 cites W2040042243 @default.
- W4319073852 cites W2044542665 @default.
- W4319073852 cites W2046772999 @default.
- W4319073852 cites W2047317780 @default.
- W4319073852 cites W2049307465 @default.
- W4319073852 cites W2052727154 @default.
- W4319073852 cites W2052756141 @default.
- W4319073852 cites W2055089903 @default.
- W4319073852 cites W2055505413 @default.
- W4319073852 cites W2055911696 @default.
- W4319073852 cites W2056252055 @default.
- W4319073852 cites W2058633478 @default.
- W4319073852 cites W2063369562 @default.
- W4319073852 cites W2063998984 @default.
- W4319073852 cites W2064567039 @default.
- W4319073852 cites W2066116773 @default.
- W4319073852 cites W2068261338 @default.
- W4319073852 cites W2075592400 @default.
- W4319073852 cites W2078057254 @default.
- W4319073852 cites W2079640624 @default.
- W4319073852 cites W2080640373 @default.
- W4319073852 cites W2081237883 @default.
- W4319073852 cites W2081664500 @default.
- W4319073852 cites W2084150522 @default.
- W4319073852 cites W2086542001 @default.
- W4319073852 cites W2087655500 @default.
- W4319073852 cites W2088073633 @default.
- W4319073852 cites W2088128469 @default.
- W4319073852 cites W2088596110 @default.
- W4319073852 cites W2090243647 @default.
- W4319073852 cites W2093678444 @default.
- W4319073852 cites W2094278454 @default.
- W4319073852 cites W2104804170 @default.
- W4319073852 cites W2106075109 @default.
- W4319073852 cites W2110258322 @default.
- W4319073852 cites W2112741705 @default.
- W4319073852 cites W2117150402 @default.
- W4319073852 cites W2119550206 @default.
- W4319073852 cites W2125187315 @default.
- W4319073852 cites W2128221594 @default.
- W4319073852 cites W2136226057 @default.
- W4319073852 cites W2137486449 @default.
- W4319073852 cites W2146536848 @default.
- W4319073852 cites W2152429732 @default.
- W4319073852 cites W2155035501 @default.
- W4319073852 cites W2162359245 @default.
- W4319073852 cites W2163887121 @default.
- W4319073852 cites W2173146841 @default.
- W4319073852 cites W2175375867 @default.
- W4319073852 cites W2178902885 @default.
- W4319073852 cites W2224598474 @default.
- W4319073852 cites W2257472368 @default.
- W4319073852 cites W2298343040 @default.