Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321749210> ?p ?o ?g. }
- W4321749210 endingPage "H570" @default.
- W4321749210 startingPage "H553" @default.
- W4321749210 abstract "Here, we investigate the potential of epidermal growth factor receptor (EGFR) inhibition to prevent vascular calcification, a leading indicator of and contributor to cardiovascular morbidity and mortality. EGFR interacts and affects the trafficking of the plasma membrane scaffolding protein caveolin-1. Previous studies reported a key role for caveolin-1 in the development of specialized extracellular vesicles that mediate vascular calcification; however, no role of EGFR has been reported. We demonstrated that EGFR inhibition modulates caveolin-1 trafficking and hinders calcifying extracellular vesicle formation, which prevents vascular calcification. Given that EGFR inhibitors are clinically approved for other indications, this may represent a novel therapeutic strategy for vascular calcification." @default.
- W4321749210 created "2023-02-25" @default.
- W4321749210 creator A5006130798 @default.
- W4321749210 creator A5009432106 @default.
- W4321749210 creator A5029817346 @default.
- W4321749210 creator A5037155552 @default.
- W4321749210 creator A5037232055 @default.
- W4321749210 creator A5052123833 @default.
- W4321749210 creator A5053233463 @default.
- W4321749210 creator A5061727742 @default.
- W4321749210 creator A5071392881 @default.
- W4321749210 creator A5091530626 @default.
- W4321749210 date "2023-04-01" @default.
- W4321749210 modified "2023-10-09" @default.
- W4321749210 title "Epidermal growth factor receptor inhibition prevents vascular calcifying extracellular vesicle biogenesis" @default.
- W4321749210 cites W1772547922 @default.
- W4321749210 cites W1966519432 @default.
- W4321749210 cites W1969123951 @default.
- W4321749210 cites W1970043144 @default.
- W4321749210 cites W1972696558 @default.
- W4321749210 cites W1974771633 @default.
- W4321749210 cites W1977687922 @default.
- W4321749210 cites W1978228345 @default.
- W4321749210 cites W2003867647 @default.
- W4321749210 cites W2007073167 @default.
- W4321749210 cites W2016208410 @default.
- W4321749210 cites W2027138842 @default.
- W4321749210 cites W2035585831 @default.
- W4321749210 cites W2040780797 @default.
- W4321749210 cites W2044167052 @default.
- W4321749210 cites W2049212536 @default.
- W4321749210 cites W2058904609 @default.
- W4321749210 cites W2061881547 @default.
- W4321749210 cites W2074062471 @default.
- W4321749210 cites W2086859574 @default.
- W4321749210 cites W2087222747 @default.
- W4321749210 cites W2088140226 @default.
- W4321749210 cites W2104237202 @default.
- W4321749210 cites W2108096529 @default.
- W4321749210 cites W2114164409 @default.
- W4321749210 cites W2135732669 @default.
- W4321749210 cites W2141023931 @default.
- W4321749210 cites W2146331622 @default.
- W4321749210 cites W2149683055 @default.
- W4321749210 cites W2149721973 @default.
- W4321749210 cites W2159616443 @default.
- W4321749210 cites W2171303601 @default.
- W4321749210 cites W2257022282 @default.
- W4321749210 cites W2295375793 @default.
- W4321749210 cites W2300406501 @default.
- W4321749210 cites W2417643138 @default.
- W4321749210 cites W2524169823 @default.
- W4321749210 cites W2551650334 @default.
- W4321749210 cites W2568505160 @default.
- W4321749210 cites W2604218568 @default.
- W4321749210 cites W2605370192 @default.
- W4321749210 cites W2616194894 @default.
- W4321749210 cites W2699220065 @default.
- W4321749210 cites W2750896603 @default.
- W4321749210 cites W2775223530 @default.
- W4321749210 cites W2783619873 @default.
- W4321749210 cites W2783810702 @default.
- W4321749210 cites W2802721666 @default.
- W4321749210 cites W2805712258 @default.
- W4321749210 cites W2805983714 @default.
- W4321749210 cites W2883936128 @default.
- W4321749210 cites W2946586244 @default.
- W4321749210 cites W2991007563 @default.
- W4321749210 cites W2993213571 @default.
- W4321749210 cites W3009962467 @default.
- W4321749210 cites W3021504553 @default.
- W4321749210 cites W3115592037 @default.
- W4321749210 cites W3121173001 @default.
- W4321749210 cites W3135005609 @default.
- W4321749210 cites W3146345978 @default.
- W4321749210 cites W4210260367 @default.
- W4321749210 cites W4242238601 @default.
- W4321749210 cites W4252076139 @default.
- W4321749210 cites W4253754191 @default.
- W4321749210 cites W4281487979 @default.
- W4321749210 doi "https://doi.org/10.1152/ajpheart.00280.2022" @default.
- W4321749210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36827229" @default.
- W4321749210 hasPublicationYear "2023" @default.
- W4321749210 type Work @default.
- W4321749210 citedByCount "1" @default.
- W4321749210 countsByYear W43217492102022 @default.
- W4321749210 crossrefType "journal-article" @default.
- W4321749210 hasAuthorship W4321749210A5006130798 @default.
- W4321749210 hasAuthorship W4321749210A5009432106 @default.
- W4321749210 hasAuthorship W4321749210A5029817346 @default.
- W4321749210 hasAuthorship W4321749210A5037155552 @default.
- W4321749210 hasAuthorship W4321749210A5037232055 @default.
- W4321749210 hasAuthorship W4321749210A5052123833 @default.
- W4321749210 hasAuthorship W4321749210A5053233463 @default.
- W4321749210 hasAuthorship W4321749210A5061727742 @default.
- W4321749210 hasAuthorship W4321749210A5071392881 @default.
- W4321749210 hasAuthorship W4321749210A5091530626 @default.
- W4321749210 hasConcept C104317684 @default.