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- W4328126390 abstract "Abstract This study evaluates the functional capacity of CD4 + and CD8 + terminally-differentiated effector (T EMRA ), central memory (T CM ), and effector memory (T EM ) cells obtained from the volunteers vaccinated with an aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac). The volunteers were followed for T cell immune responses following the termination of a randomized phase III clinical trial. Seven days and four months after the second dose of the vaccine, the memory T cell subsets were collected and stimulated by autologous monocyte-derived dendritic cells (mDCs) loaded with SARS-CoV-2 spike glycoprotein S1. Compared to the placebo group, memory T cells from the vaccinated individuals significantly proliferated in response to S1-loaded mDCs. CD4 + and CD8 + memory T cell proliferation was detected in 86% and 78% of the vaccinated individuals, respectively. More than 73% (after a short-term) and 62% (after an intermediate-term) of the vaccinated individuals harbored T CM and/or T EM cells that responded to S1-loaded mDCs by secreting IFN-γ. The expression of CD25, CD38, 4-1BB, PD-1, and CD107a indicated a modulation in the memory T cell subsets. Especially on day 120, PD-1 was upregulated on CD4 + T EMRA and T CM , and on CD8 + T EM and T CM cells; accordingly, proliferation and IFN-γ secretion capacities tended to decline after 4 months. In conclusion, the combination of inactivated whole-virion particles with aluminum adjuvants possesses capacities to induce functional T cell responses." @default.
- W4328126390 created "2023-03-22" @default.
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- W4328126390 date "2023-03-21" @default.
- W4328126390 modified "2023-09-27" @default.
- W4328126390 title "Human memory T cell dynamics after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccination" @default.
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- W4328126390 doi "https://doi.org/10.1038/s41598-023-31347-8" @default.
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