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• W4360795056 abstract "OBJECTIVE Stereotactic conformal radiotherapy (SCRT) is a high precision technique of fractionated radiotherapy which ensures accurate delivery of radiation with reduction in the volume of normal tissue irradiated as compared to conventional external beam radiotherapy. We describe the technique and preliminary experience of SCRT in patients with residual and recurrent pituitary adenomas. PATIENTS AND METHODS Between February 1995 and March 1999, 22 patients (mean age: 45.3, range: 20–67 years) with residual or recurrent pituitary adenomas (13 nonfunctioning, nine secretory) were treated with SCRT. All were immobilized in a relocatable Gill–Thomas–Cosman (GTC) frame and tumour was localized on a postcontrast planning computerized tomography (CT) and MRI scan. The gross tumour volume (GTV) and the critical structures were outlined on contiguous 2–3 mm separated slices. A margin of 5 mm (12 patients) to 10 mm (10 patients) was grown around GTV in three‐dimensions (3‐D) to generate the planning target volume (PTV). The treatment was delivered by three (five patients) and four (17 patients) maximally separated conformal fixed fields with each field conformed to the shape of the tumour using customized lead alloy blocks (19 patients) or multileaf collimator (three patients). The patients were treated on a 6‐MV linear accelerator to a dose of 45 Gy in 25 fractions (18 patients) and 50 Gy in 30 fractions (four patients). RESULTS The technique of SCRT has become a part of the routine work of the radiotherapy department. The treatment was well tolerated with minimal acute toxicity. One patient developed transient quadrantanopia 2 weeks after treatment with full recovery after a short course of corticosteroids. One patient had a transient visual deterioration 7 months after treatment due to cystic degeneration of the tumour which fully recovered following surgical decompression. Nine of the 15 patients presenting with visual impairment had improvement after treatment and the visual status remained stable in all others. One patient with acromegaly and one with a prolactinoma achieved normalization of elevated hormonal abnormality four and 10 months after SCRT, respectively. The remaining seven patients with a secretory adenoma had declining hormone levels at last follow‐up. Newly initiated hormone replacement therapy was required in five patients. At a median follow‐up of 9 months (range 1–44 months), the 1 and 2 year actuarial progression free and overall survival were 100%. CONCLUSION Stereotactic conformal radiotherapy is a high precision technique suitable for the treatment of pituitary adenomas requiring radiotherapy. Preliminary results suggest effective tumour control and low toxicity within the range expected for conventional external beam radiotherapy. While the technique is of potential benefit in reducing the volume of normal brain irradiated, the advantages in terms of sustained tumour control and reduced toxicity over conventional radiotherapy need to be demonstrated in long‐term prospective studies." @default.
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• W4360795056 date "2000-06-01" @default.
• W4360795056 modified "2023-10-16" @default.
• W4360795056 title "Stereotactic conformal radiotherapy for pituitary adenomas: technique and preliminary experience" @default.
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• W4360795056 cites W1963966171 @default.
• W4360795056 cites W1967588768 @default.
• W4360795056 cites W1968386365 @default.
• W4360795056 cites W1971866642 @default.
• W4360795056 cites W1973059597 @default.
• W4360795056 cites W1976019618 @default.
• W4360795056 cites W1976457622 @default.
• W4360795056 cites W1979117753 @default.
• W4360795056 cites W1979911737 @default.
• W4360795056 cites W1991625499 @default.
• W4360795056 cites W1992170951 @default.
• W4360795056 cites W1992347733 @default.
• W4360795056 cites W1992537443 @default.
• W4360795056 cites W1995656165 @default.
• W4360795056 cites W1997189844 @default.
• W4360795056 cites W1997583934 @default.
• W4360795056 cites W1997764459 @default.
• W4360795056 cites W2003811574 @default.
• W4360795056 cites W2006812243 @default.
• W4360795056 cites W2007761389 @default.
• W4360795056 cites W2013860854 @default.
• W4360795056 cites W2014818783 @default.
• W4360795056 cites W2016950386 @default.
• W4360795056 cites W2024424969 @default.
• W4360795056 cites W2026306988 @default.
• W4360795056 cites W2035757278 @default.
• W4360795056 cites W2040215672 @default.
• W4360795056 cites W2040844610 @default.
• W4360795056 cites W2043789200 @default.
• W4360795056 cites W2045919150 @default.
• W4360795056 cites W2049215489 @default.
• W4360795056 cites W2055928489 @default.
• W4360795056 cites W2063278239 @default.
• W4360795056 cites W2066907256 @default.
• W4360795056 cites W2069064354 @default.
• W4360795056 cites W2069198455 @default.
• W4360795056 cites W2073005838 @default.
• W4360795056 cites W2075181027 @default.
• W4360795056 cites W2075887192 @default.
• W4360795056 cites W2078305681 @default.
• W4360795056 cites W2078680569 @default.
• W4360795056 cites W2085959790 @default.
• W4360795056 cites W2101697825 @default.
• W4360795056 cites W2112333204 @default.
• W4360795056 cites W2122615735 @default.
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• W4360795056 doi "https://doi.org/10.1046/j.1365-2265.2000.00967.x" @default.
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