FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366990327> ?p ?o ?g. }

• W4366990327 abstract "Oral squamous cell carcinoma (OSCC) escape from the immune system is mediated through several immunosuppressive phenotypes that are critical to the initiation and progression of tumors. As a hallmark of cancer, DNA damage repair is closely related to changes in the immunophenotypes of tumor cells. Although flap endonuclease-1 (FEN1), a pivotal DNA-related enzyme is involved in DNA base excision repair to maintain the stability of the cell genome, the correlation between FEN1 and tumor immunity has been unexplored. In the current study, by analyzing the clinicopathological characteristics of FEN1, we demonstrated that FEN1 overexpressed and that an inhibitory immune microenvironment was established in OSCC. In addition, we found that downregulating FEN1 inhibited the growth of OSCC tumors. In vitro studies provided evidence that FEN1 knockdown inhibited the biological behaviors of OSCC and caused DNA damage. Performing multiplex immunohistochemistry (mIHC), we directly observed that the acquisition of critical immunosuppressive phenotypes was correlated with the expression of FEN1. More importantly, FEN1 directly or indirectly regulated two typical immunosuppressive phenotype-related proteins human leukocyte antigen (HLA-DR) and programmed death receptor ligand 1 (PD-L1), through the interferon-gamma (IFN-γ)/janus kinase (JAK)/signal transducer and activator transcription 1 (STAT1) pathway. Our study highlights a new perspective on FEN1 action for the first time, providing theoretical evidence that it may be a potential immunotherapy target for OSCC." @default.
• W4366990327 created "2023-04-27" @default.
• W4366990327 creator A5000705197 @default.
• W4366990327 creator A5018467739 @default.
• W4366990327 creator A5035856821 @default.
• W4366990327 creator A5047519519 @default.
• W4366990327 creator A5062615330 @default.
• W4366990327 creator A5064222496 @default.
• W4366990327 creator A5085242835 @default.
• W4366990327 date "2023-04-25" @default.
• W4366990327 modified "2023-10-16" @default.
• W4366990327 title "Down-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-γ/JAK/STAT-1" @default.
• W4366990327 cites W1974349751 @default.
• W4366990327 cites W2017324980 @default.
• W4366990327 cites W2046152711 @default.
• W4366990327 cites W2060070314 @default.
• W4366990327 cites W2100626549 @default.
• W4366990327 cites W2121626779 @default.
• W4366990327 cites W2124231680 @default.
• W4366990327 cites W2154555637 @default.
• W4366990327 cites W2162451014 @default.
• W4366990327 cites W2166672594 @default.
• W4366990327 cites W2307487014 @default.
• W4366990327 cites W2465142962 @default.
• W4366990327 cites W2520059810 @default.
• W4366990327 cites W2560367415 @default.
• W4366990327 cites W2603131111 @default.
• W4366990327 cites W2612431515 @default.
• W4366990327 cites W2761795872 @default.
• W4366990327 cites W2768434280 @default.
• W4366990327 cites W2790574591 @default.
• W4366990327 cites W2792850129 @default.
• W4366990327 cites W2794513289 @default.
• W4366990327 cites W2796858753 @default.
• W4366990327 cites W2800818313 @default.
• W4366990327 cites W2801894898 @default.
• W4366990327 cites W2802409103 @default.
• W4366990327 cites W2802731336 @default.
• W4366990327 cites W2894717949 @default.
• W4366990327 cites W2895441403 @default.
• W4366990327 cites W2902939286 @default.
• W4366990327 cites W2914447215 @default.
• W4366990327 cites W2947574275 @default.
• W4366990327 cites W2951756816 @default.
• W4366990327 cites W2955029074 @default.
• W4366990327 cites W2959625518 @default.
• W4366990327 cites W2971735282 @default.
• W4366990327 cites W2972212968 @default.
• W4366990327 cites W2972412203 @default.
• W4366990327 cites W2982130750 @default.
• W4366990327 cites W2998871098 @default.
• W4366990327 cites W3002834433 @default.
• W4366990327 cites W3011706593 @default.
• W4366990327 cites W3014817317 @default.
• W4366990327 cites W3034044852 @default.
• W4366990327 cites W3080088791 @default.
• W4366990327 cites W3090386083 @default.
• W4366990327 cites W3093455561 @default.
• W4366990327 cites W3120818551 @default.
• W4366990327 cites W3136328381 @default.
• W4366990327 cites W3157108217 @default.
• W4366990327 cites W3171648992 @default.
• W4366990327 cites W3204131907 @default.
• W4366990327 cites W3205706383 @default.
• W4366990327 cites W4207007699 @default.
• W4366990327 cites W4225529913 @default.
• W4366990327 cites W4234255852 @default.
• W4366990327 cites W4286002146 @default.
• W4366990327 cites W4303628910 @default.
• W4366990327 doi "https://doi.org/10.1038/s41368-023-00221-8" @default.
• W4366990327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37185662" @default.
• W4366990327 hasPublicationYear "2023" @default.
• W4366990327 type Work @default.
• W4366990327 citedByCount "1" @default.
• W4366990327 countsByYear W43669903272023 @default.
• W4366990327 crossrefType "journal-article" @default.
• W4366990327 hasAuthorship W4366990327A5000705197 @default.
• W4366990327 hasAuthorship W4366990327A5018467739 @default.
• W4366990327 hasAuthorship W4366990327A5035856821 @default.
• W4366990327 hasAuthorship W4366990327A5047519519 @default.
• W4366990327 hasAuthorship W4366990327A5062615330 @default.
• W4366990327 hasAuthorship W4366990327A5064222496 @default.
• W4366990327 hasAuthorship W4366990327A5085242835 @default.
• W4366990327 hasBestOaLocation W43669903271 @default.
• W4366990327 hasConcept C112392421 @default.
• W4366990327 hasConcept C134935766 @default.
• W4366990327 hasConcept C143425029 @default.
• W4366990327 hasConcept C157333092 @default.
• W4366990327 hasConcept C171958077 @default.
• W4366990327 hasConcept C203014093 @default.
• W4366990327 hasConcept C2776178377 @default.
• W4366990327 hasConcept C2777003663 @default.
• W4366990327 hasConcept C2778923194 @default.
• W4366990327 hasConcept C34688535 @default.
• W4366990327 hasConcept C42362537 @default.
• W4366990327 hasConcept C502942594 @default.
• W4366990327 hasConcept C54355233 @default.
• W4366990327 hasConcept C552990157 @default.
• W4366990327 hasConcept C62112901 @default.
• W4366990327 hasConcept C62478195 @default.

• next