FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366991925> ?p ?o ?g. }

• W4366991925 endingPage "021" @default.
• W4366991925 startingPage "017" @default.
• W4366991925 abstract "There is an urgent need for predictive preclinical models to enhance the success rate of clinical trial outcomes. One of the main reasons for drug attrition is the lack of translational models, methods using human cells are particularly in the spotlight of regulatory bodies as they offer an alternative to in vivo studies and have the potential to improve the translational of preclinical trials. Organs-on-Chips (OoCs) are sensible candidates to reduce the cost and the ethical burden of animal models while accelerating and de-risking drug development. The innovation of such systems is based on both the increased relevance of the cells used and the ability to build precise, yet physiologically relevant, complex architectures. The use of microfluidic technologies with human induced pluripotent stem cells (hiPSCs) opens new routes to create relevant in vitro approaches as they will soon be able to reproduce clinical characteristics of donors or specific populations. The adoption of OoC models by pharmaceutical industries, and in fine by regulatory agencies, still requires: (i) establishing standardized, reproducible, robust, and replicable cell culture protocols with specific validation and characterization criteria, (ii) evidence that the technology predicts human responses, thus allowing to contribute efficiently and reliably to clinical trials success of novel therapeutics, and (iii) evidence that the models refine and reduce animal testing without compromising with the quality and the pertinence of the data generated." @default.
• W4366991925 created "2023-04-27" @default.
• W4366991925 creator A5016847549 @default.
• W4366991925 creator A5038010940 @default.
• W4366991925 creator A5086508239 @default.
• W4366991925 date "2023-04-13" @default.
• W4366991925 modified "2023-09-26" @default.
• W4366991925 title "Expanding human-based predictive models capabilities using organs-on-chip: A standardized framework to transfer and co-culture human iPSCs into microfluidic devices" @default.
• W4366991925 cites W1847104216 @default.
• W4366991925 cites W2062279417 @default.
• W4366991925 cites W2138977668 @default.
• W4366991925 cites W2161817427 @default.
• W4366991925 cites W2520107693 @default.
• W4366991925 cites W2765115077 @default.
• W4366991925 cites W2799449856 @default.
• W4366991925 cites W2885351238 @default.
• W4366991925 cites W2936828686 @default.
• W4366991925 cites W2963027449 @default.
• W4366991925 cites W2964627277 @default.
• W4366991925 cites W2983879675 @default.
• W4366991925 cites W3092983038 @default.
• W4366991925 cites W3131552452 @default.
• W4366991925 cites W3133862951 @default.
• W4366991925 cites W3188744629 @default.
• W4366991925 cites W3190255015 @default.
• W4366991925 cites W4213098544 @default.
• W4366991925 cites W4220652963 @default.
• W4366991925 cites W4283461330 @default.
• W4366991925 cites W4306362099 @default.
• W4366991925 cites W4307548858 @default.
• W4366991925 doi "https://doi.org/10.29328/journal.apps.1001039" @default.
• W4366991925 hasPublicationYear "2023" @default.
• W4366991925 type Work @default.
• W4366991925 citedByCount "0" @default.
• W4366991925 crossrefType "journal-article" @default.
• W4366991925 hasAuthorship W4366991925A5016847549 @default.
• W4366991925 hasAuthorship W4366991925A5038010940 @default.
• W4366991925 hasAuthorship W4366991925A5086508239 @default.
• W4366991925 hasBestOaLocation W43669919251 @default.
• W4366991925 hasConcept C104317684 @default.
• W4366991925 hasConcept C107459253 @default.
• W4366991925 hasConcept C112930515 @default.
• W4366991925 hasConcept C127413603 @default.
• W4366991925 hasConcept C128544194 @default.
• W4366991925 hasConcept C145103041 @default.
• W4366991925 hasConcept C150903083 @default.
• W4366991925 hasConcept C183696295 @default.
• W4366991925 hasConcept C19527891 @default.
• W4366991925 hasConcept C2522767166 @default.
• W4366991925 hasConcept C2779652045 @default.
• W4366991925 hasConcept C2780035454 @default.
• W4366991925 hasConcept C2994543053 @default.
• W4366991925 hasConcept C41008148 @default.
• W4366991925 hasConcept C535046627 @default.
• W4366991925 hasConcept C55493867 @default.
• W4366991925 hasConcept C60644358 @default.
• W4366991925 hasConcept C64903051 @default.
• W4366991925 hasConcept C70721500 @default.
• W4366991925 hasConcept C71924100 @default.
• W4366991925 hasConcept C74187038 @default.
• W4366991925 hasConcept C86803240 @default.
• W4366991925 hasConcept C98274493 @default.
• W4366991925 hasConceptScore W4366991925C104317684 @default.
• W4366991925 hasConceptScore W4366991925C107459253 @default.
• W4366991925 hasConceptScore W4366991925C112930515 @default.
• W4366991925 hasConceptScore W4366991925C127413603 @default.
• W4366991925 hasConceptScore W4366991925C128544194 @default.
• W4366991925 hasConceptScore W4366991925C145103041 @default.
• W4366991925 hasConceptScore W4366991925C150903083 @default.
• W4366991925 hasConceptScore W4366991925C183696295 @default.
• W4366991925 hasConceptScore W4366991925C19527891 @default.
• W4366991925 hasConceptScore W4366991925C2522767166 @default.
• W4366991925 hasConceptScore W4366991925C2779652045 @default.
• W4366991925 hasConceptScore W4366991925C2780035454 @default.
• W4366991925 hasConceptScore W4366991925C2994543053 @default.
• W4366991925 hasConceptScore W4366991925C41008148 @default.
• W4366991925 hasConceptScore W4366991925C535046627 @default.
• W4366991925 hasConceptScore W4366991925C55493867 @default.
• W4366991925 hasConceptScore W4366991925C60644358 @default.
• W4366991925 hasConceptScore W4366991925C64903051 @default.
• W4366991925 hasConceptScore W4366991925C70721500 @default.
• W4366991925 hasConceptScore W4366991925C71924100 @default.
• W4366991925 hasConceptScore W4366991925C74187038 @default.
• W4366991925 hasConceptScore W4366991925C86803240 @default.
• W4366991925 hasConceptScore W4366991925C98274493 @default.
• W4366991925 hasIssue "1" @default.
• W4366991925 hasLocation W43669919251 @default.
• W4366991925 hasOpenAccess W4366991925 @default.
• W4366991925 hasPrimaryLocation W43669919251 @default.
• W4366991925 hasRelatedWork W1973476709 @default.
• W4366991925 hasRelatedWork W2023605055 @default.
• W4366991925 hasRelatedWork W2033247361 @default.
• W4366991925 hasRelatedWork W2170409651 @default.
• W4366991925 hasRelatedWork W2197714088 @default.
• W4366991925 hasRelatedWork W2365200240 @default.
• W4366991925 hasRelatedWork W2387795498 @default.
• W4366991925 hasRelatedWork W2566664155 @default.
• W4366991925 hasRelatedWork W2593321755 @default.

• next