Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366993032> ?p ?o ?g. }
- W4366993032 endingPage "2064.e6" @default.
- W4366993032 startingPage "2051" @default.
- W4366993032 abstract "Activity-dependent expression of immediate early genes (IEGs) is critical for long-term synaptic remodeling and memory. It remains unknown how IEGs are maintained for memory despite rapid transcript and protein turnover. To address this conundrum, we monitored Arc, an IEG essential for memory consolidation. Using a knockin mouse where endogenous Arc alleles were fluorescently tagged, we performed real-time imaging of Arc mRNA dynamics in individual neurons in cultures and brain tissue. Unexpectedly, a single burst stimulation was sufficient to induce cycles of transcriptional reactivation in the same neuron. Subsequent transcription cycles required translation, whereby new Arc proteins engaged in autoregulatory positive feedback to reinduce transcription. The ensuing Arc mRNAs preferentially localized at sites marked by previous Arc protein, assembling a “hotspot” of translation, and consolidating “hubs” of dendritic Arc. These cycles of transcription-translation coupling sustain protein expression and provide a mechanism by which a short-lived event may support long-term memory." @default.
- W4366993032 created "2023-04-27" @default.
- W4366993032 creator A5039622415 @default.
- W4366993032 creator A5051069055 @default.
- W4366993032 creator A5081456245 @default.
- W4366993032 creator A5089504365 @default.
- W4366993032 date "2023-07-01" @default.
- W4366993032 modified "2023-10-11" @default.
- W4366993032 title "Maintenance of a short-lived protein required for long-term memory involves cycles of transcription and local translation" @default.
- W4366993032 cites W1937172266 @default.
- W4366993032 cites W1966901093 @default.
- W4366993032 cites W1993696200 @default.
- W4366993032 cites W1995001752 @default.
- W4366993032 cites W1995549311 @default.
- W4366993032 cites W2013185658 @default.
- W4366993032 cites W2015252454 @default.
- W4366993032 cites W2017842407 @default.
- W4366993032 cites W2019976089 @default.
- W4366993032 cites W2021253208 @default.
- W4366993032 cites W2024386053 @default.
- W4366993032 cites W2024465869 @default.
- W4366993032 cites W2028569071 @default.
- W4366993032 cites W2029712849 @default.
- W4366993032 cites W2032057219 @default.
- W4366993032 cites W2033026245 @default.
- W4366993032 cites W2036581163 @default.
- W4366993032 cites W2041101385 @default.
- W4366993032 cites W2042834556 @default.
- W4366993032 cites W2050552159 @default.
- W4366993032 cites W2050849480 @default.
- W4366993032 cites W2054855377 @default.
- W4366993032 cites W2059856205 @default.
- W4366993032 cites W2065380916 @default.
- W4366993032 cites W2070739894 @default.
- W4366993032 cites W2072949646 @default.
- W4366993032 cites W2074497182 @default.
- W4366993032 cites W2075803148 @default.
- W4366993032 cites W2077468928 @default.
- W4366993032 cites W2082832087 @default.
- W4366993032 cites W2088242217 @default.
- W4366993032 cites W2088762048 @default.
- W4366993032 cites W2094780410 @default.
- W4366993032 cites W2100699923 @default.
- W4366993032 cites W2102973376 @default.
- W4366993032 cites W2108080167 @default.
- W4366993032 cites W2114559471 @default.
- W4366993032 cites W2121198501 @default.
- W4366993032 cites W2122682406 @default.
- W4366993032 cites W2126772993 @default.
- W4366993032 cites W2152336488 @default.
- W4366993032 cites W2160769038 @default.
- W4366993032 cites W2162591320 @default.
- W4366993032 cites W2167423431 @default.
- W4366993032 cites W2167436769 @default.
- W4366993032 cites W2169373177 @default.
- W4366993032 cites W2203645773 @default.
- W4366993032 cites W2298086467 @default.
- W4366993032 cites W2337142160 @default.
- W4366993032 cites W2346053509 @default.
- W4366993032 cites W2346619804 @default.
- W4366993032 cites W2469423203 @default.
- W4366993032 cites W2536806087 @default.
- W4366993032 cites W2591328465 @default.
- W4366993032 cites W2605776475 @default.
- W4366993032 cites W2805844509 @default.
- W4366993032 cites W2808931657 @default.
- W4366993032 cites W2898137459 @default.
- W4366993032 cites W2898615423 @default.
- W4366993032 cites W2906180136 @default.
- W4366993032 cites W2914830318 @default.
- W4366993032 cites W2950828985 @default.
- W4366993032 cites W2953683903 @default.
- W4366993032 cites W3048941542 @default.
- W4366993032 cites W3102239735 @default.
- W4366993032 cites W3138498421 @default.
- W4366993032 cites W3152172570 @default.
- W4366993032 cites W3154051819 @default.
- W4366993032 cites W3199862509 @default.
- W4366993032 cites W4212998675 @default.
- W4366993032 cites W4295308901 @default.
- W4366993032 cites W4308147523 @default.
- W4366993032 doi "https://doi.org/10.1016/j.neuron.2023.04.005" @default.
- W4366993032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37100055" @default.
- W4366993032 hasPublicationYear "2023" @default.
- W4366993032 type Work @default.
- W4366993032 citedByCount "1" @default.
- W4366993032 crossrefType "journal-article" @default.
- W4366993032 hasAuthorship W4366993032A5039622415 @default.
- W4366993032 hasAuthorship W4366993032A5051069055 @default.
- W4366993032 hasAuthorship W4366993032A5081456245 @default.
- W4366993032 hasAuthorship W4366993032A5089504365 @default.
- W4366993032 hasBestOaLocation W43669930321 @default.
- W4366993032 hasConcept C104317684 @default.
- W4366993032 hasConcept C105580179 @default.
- W4366993032 hasConcept C138885662 @default.
- W4366993032 hasConcept C150194340 @default.
- W4366993032 hasConcept C169760540 @default.
- W4366993032 hasConcept C179926584 @default.