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- W4366993219 endingPage "154482" @default.
- W4366993219 startingPage "154482" @default.
- W4366993219 abstract "Breast cancer is the most frequently diagnosed malignancy in women and a major public health concern. In the current report, differential expression of the breast cancer resistance promoting genes with a focus on breast cancer stem cell related elements as well as the correlation of their mRNAs with various clinicopathologic characteristics, including molecular subtypes, tumor grade/stage, and methylation status, have been investigated using METABRIC and TCGA datasets. To achieve this goal, we downloaded gene expression data of breast cancer patients from TCGA and METABRIC. Then, statistical analyses were used to assess the correlation between the expression levels of stem cell related drug resistant genes and methylation status, tumor grades, various molecular subtypes, and some cancer hallmark gene sets such as immune evasion, metastasis, and angiogenesis. According to the results of this study, a number of stem cell related drug resistant genes are deregulated in breast cancer patients. Furthermore, we observe negative correlations between methylation of resistance genes and mRNA expression. There is a significant difference in the expression of resistance-promoting genes between different molecular subtypes. As mRNA expression and DNA methylation are clearly related, DNA methylation might be a mechanism that regulates these genes in breast cancer cells. As indicated by the differential expression of resistance-promoting genes among various breast cancer molecular subtypes, these genes may function differently in different subtypes of breast cancer. In conclusion, significant deregulation of resistance-promoting factors indicates that these genes may play a significant role in the development of breast cancer." @default.
- W4366993219 created "2023-04-27" @default.
- W4366993219 creator A5009302000 @default.
- W4366993219 creator A5037156059 @default.
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- W4366993219 creator A5078858622 @default.
- W4366993219 creator A5087812545 @default.
- W4366993219 creator A5090236421 @default.
- W4366993219 date "2023-06-01" @default.
- W4366993219 modified "2023-09-29" @default.
- W4366993219 title "Cancer stem cell-mediated drug resistance: A comprehensive gene expression profile analysis in breast cancer" @default.
- W4366993219 cites W1438161774 @default.
- W4366993219 cites W1511246213 @default.
- W4366993219 cites W1595172861 @default.
- W4366993219 cites W1970336739 @default.
- W4366993219 cites W1972897125 @default.
- W4366993219 cites W1982273978 @default.
- W4366993219 cites W1984469163 @default.
- W4366993219 cites W1984484474 @default.
- W4366993219 cites W1990261336 @default.
- W4366993219 cites W1992330510 @default.
- W4366993219 cites W1993494709 @default.
- W4366993219 cites W2002403202 @default.
- W4366993219 cites W2004630197 @default.
- W4366993219 cites W2011923111 @default.
- W4366993219 cites W2012431429 @default.
- W4366993219 cites W2012718299 @default.
- W4366993219 cites W2038289755 @default.
- W4366993219 cites W2042166975 @default.
- W4366993219 cites W2042890253 @default.
- W4366993219 cites W2044006084 @default.
- W4366993219 cites W2048558726 @default.
- W4366993219 cites W2052834898 @default.
- W4366993219 cites W2062186391 @default.
- W4366993219 cites W2067100741 @default.
- W4366993219 cites W2073135247 @default.
- W4366993219 cites W2076295610 @default.
- W4366993219 cites W2076971387 @default.
- W4366993219 cites W2080879903 @default.
- W4366993219 cites W2083314681 @default.
- W4366993219 cites W2088936299 @default.
- W4366993219 cites W2096986950 @default.
- W4366993219 cites W2100438302 @default.
- W4366993219 cites W2102810283 @default.
- W4366993219 cites W2104849855 @default.
- W4366993219 cites W2109579983 @default.
- W4366993219 cites W2110567472 @default.
- W4366993219 cites W2111984765 @default.
- W4366993219 cites W2115189949 @default.
- W4366993219 cites W2118106551 @default.
- W4366993219 cites W2123173724 @default.
- W4366993219 cites W2123583989 @default.
- W4366993219 cites W2126585177 @default.
- W4366993219 cites W2137522359 @default.
- W4366993219 cites W2139444209 @default.
- W4366993219 cites W2139517025 @default.
- W4366993219 cites W2140878328 @default.
- W4366993219 cites W2158485828 @default.
- W4366993219 cites W2163433610 @default.
- W4366993219 cites W2200390204 @default.
- W4366993219 cites W2227211170 @default.
- W4366993219 cites W2359219670 @default.
- W4366993219 cites W2471187111 @default.
- W4366993219 cites W2505837694 @default.
- W4366993219 cites W2512931560 @default.
- W4366993219 cites W2557509406 @default.
- W4366993219 cites W2590280648 @default.
- W4366993219 cites W2603080392 @default.
- W4366993219 cites W2611412386 @default.
- W4366993219 cites W2619656708 @default.
- W4366993219 cites W2728594144 @default.
- W4366993219 cites W2749262613 @default.
- W4366993219 cites W2760328201 @default.
- W4366993219 cites W2768576952 @default.
- W4366993219 cites W2772618424 @default.
- W4366993219 cites W2773992597 @default.
- W4366993219 cites W2774736917 @default.
- W4366993219 cites W2793234310 @default.
- W4366993219 cites W2803763439 @default.
- W4366993219 cites W2803908182 @default.
- W4366993219 cites W2804574021 @default.
- W4366993219 cites W2805449948 @default.
- W4366993219 cites W2884390993 @default.
- W4366993219 cites W2939330838 @default.
- W4366993219 cites W2942953006 @default.
- W4366993219 cites W2957817001 @default.
- W4366993219 cites W2971798461 @default.
- W4366993219 cites W2991310970 @default.
- W4366993219 cites W2995695923 @default.
- W4366993219 cites W3012044499 @default.
- W4366993219 cites W3017339791 @default.
- W4366993219 cites W3018862687 @default.
- W4366993219 cites W3022589289 @default.
- W4366993219 cites W3027259655 @default.
- W4366993219 cites W3027483951 @default.