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• W4378515464 endingPage "1393" @default.
• W4378515464 startingPage "1393" @default.
• W4378515464 abstract "The relationship between chronic intestinal disease, including inflammatory bowel disease (IBD) and celiac disease (CelD), and pancreatic disorders has been little investigated. Although an increased risk of acute pancreatitis (AP), exocrine pancreatic insufficiency with or without chronic pancreatitis, and chronic asymptomatic pancreatic hyperenzymemia have been described in these patients, the pathogenetic link remains unclear. It may potentially involve drugs, altered microcirculation, gut permeability/motility with disruption of enteric-mediated hormone secretion, bacterial translocation, and activation of the gut-associated lymphoid tissue related to chronic inflammation. In addition, the risk of pancreatic cancer seems to be increased in both IBD and CelD patients with unknown pathogenesis. Finally, other systemic conditions (e.g., IgG4-related disease, sarcoidosis, vasculitides) might affect pancreatic gland and the intestinal tract with various clinical manifestations. This review includes the current understandings of this enigmatic association, reporting a clinical and pathophysiological overview about this topic." @default.
• W4378515464 created "2023-05-28" @default.
• W4378515464 creator A5007594153 @default.
• W4378515464 creator A5028819527 @default.
• W4378515464 creator A5032939859 @default.
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• W4378515464 creator A5032987087 @default.
• W4378515464 creator A5067892973 @default.
• W4378515464 creator A5069023355 @default.
• W4378515464 creator A5087245255 @default.
• W4378515464 date "2023-05-08" @default.
• W4378515464 modified "2023-10-16" @default.
• W4378515464 title "A Clinical and Pathophysiological Overview of Intestinal and Systemic Diseases Associated with Pancreatic Disorders: Causality or Casualty?" @default.
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