Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378528064> ?p ?o ?g. }
- W4378528064 endingPage "2940" @default.
- W4378528064 startingPage "2940" @default.
- W4378528064 abstract "Malignant pleural mesothelioma (MPM) is a malignancy associated with asbestos exposure and is typically categorized as an orphan disease. Recent developments in immunotherapy with anti-PD-1 and anti-CTLA-4 antibodies, specifically with agents nivolumab and ipilimumab, have demonstrated an improvement in overall survival over the previous standard chemotherapy leading to their FDA-approval as first-line therapy for unresectable disease. For quite some time, it has been known that these proteins are not the only ones that function as immune checkpoints in human biology, and the hypothesis that MPM is an immunogenic disease has led to an expanding number of studies investigating alternative checkpoint inhibitors and novel immunotherapy for this malignancy. Early trials are also supporting the notion that therapies that target biological molecules on T cells, cancer cells, or that trigger the antitumor activity of other immune cells may represent the future of MPM treatment. Moreover, mesothelin-targeted therapies are thriving in the field, with forthcoming results from multiple trials signaling an improvement in overall survival when combined with other immunotherapy agents. The following manuscript will review the current state of immune therapy for MPM, explore the knowledge gaps in the field, and discuss ongoing novel immunotherapeutic research in early clinical trials." @default.
- W4378528064 created "2023-05-28" @default.
- W4378528064 creator A5033349344 @default.
- W4378528064 creator A5054109991 @default.
- W4378528064 creator A5061702293 @default.
- W4378528064 date "2023-05-27" @default.
- W4378528064 modified "2023-10-01" @default.
- W4378528064 title "Success of Checkpoint Blockade Paves the Way for Novel Immune Therapy in Malignant Pleural Mesothelioma" @default.
- W4378528064 cites W1916029918 @default.
- W4378528064 cites W1926256541 @default.
- W4378528064 cites W2013617462 @default.
- W4378528064 cites W2031203833 @default.
- W4378528064 cites W2102627969 @default.
- W4378528064 cites W2120633194 @default.
- W4378528064 cites W2130276477 @default.
- W4378528064 cites W2132921981 @default.
- W4378528064 cites W2145255008 @default.
- W4378528064 cites W2157408208 @default.
- W4378528064 cites W2215044613 @default.
- W4378528064 cites W2460247111 @default.
- W4378528064 cites W2461057056 @default.
- W4378528064 cites W2484808989 @default.
- W4378528064 cites W2531335004 @default.
- W4378528064 cites W2568843818 @default.
- W4378528064 cites W2593193817 @default.
- W4378528064 cites W2734373861 @default.
- W4378528064 cites W2742489071 @default.
- W4378528064 cites W2751695648 @default.
- W4378528064 cites W2766967575 @default.
- W4378528064 cites W2773000470 @default.
- W4378528064 cites W2794056047 @default.
- W4378528064 cites W2795515854 @default.
- W4378528064 cites W2801062708 @default.
- W4378528064 cites W2885621541 @default.
- W4378528064 cites W2898156664 @default.
- W4378528064 cites W2898263414 @default.
- W4378528064 cites W2907561635 @default.
- W4378528064 cites W2908887190 @default.
- W4378528064 cites W2909198142 @default.
- W4378528064 cites W2946234641 @default.
- W4378528064 cites W2948619068 @default.
- W4378528064 cites W2955432103 @default.
- W4378528064 cites W2977339506 @default.
- W4378528064 cites W2994978090 @default.
- W4378528064 cites W3006756187 @default.
- W4378528064 cites W3089914738 @default.
- W4378528064 cites W3098248396 @default.
- W4378528064 cites W3122627530 @default.
- W4378528064 cites W3152842877 @default.
- W4378528064 cites W3157347420 @default.
- W4378528064 cites W3165195007 @default.
- W4378528064 cites W3168834502 @default.
- W4378528064 cites W3171695759 @default.
- W4378528064 cites W3174122195 @default.
- W4378528064 cites W3175991011 @default.
- W4378528064 cites W3179214161 @default.
- W4378528064 cites W3183409909 @default.
- W4378528064 cites W3193921772 @default.
- W4378528064 cites W3197936962 @default.
- W4378528064 cites W3207665479 @default.
- W4378528064 cites W3209224491 @default.
- W4378528064 cites W3211455418 @default.
- W4378528064 cites W4206964867 @default.
- W4378528064 cites W4226407945 @default.
- W4378528064 cites W4281721227 @default.
- W4378528064 cites W4294943498 @default.
- W4378528064 cites W3188786189 @default.
- W4378528064 doi "https://doi.org/10.3390/cancers15112940" @default.
- W4378528064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37296902" @default.
- W4378528064 hasPublicationYear "2023" @default.
- W4378528064 type Work @default.
- W4378528064 citedByCount "1" @default.
- W4378528064 countsByYear W43785280642023 @default.
- W4378528064 crossrefType "journal-article" @default.
- W4378528064 hasAuthorship W4378528064A5033349344 @default.
- W4378528064 hasAuthorship W4378528064A5054109991 @default.
- W4378528064 hasAuthorship W4378528064A5061702293 @default.
- W4378528064 hasBestOaLocation W43785280641 @default.
- W4378528064 hasConcept C121608353 @default.
- W4378528064 hasConcept C126322002 @default.
- W4378528064 hasConcept C142724271 @default.
- W4378528064 hasConcept C143998085 @default.
- W4378528064 hasConcept C203014093 @default.
- W4378528064 hasConcept C2777407522 @default.
- W4378528064 hasConcept C2777701055 @default.
- W4378528064 hasConcept C2779399171 @default.
- W4378528064 hasConcept C2780030458 @default.
- W4378528064 hasConcept C2780851360 @default.
- W4378528064 hasConcept C2781230642 @default.
- W4378528064 hasConcept C2781433595 @default.
- W4378528064 hasConcept C502942594 @default.
- W4378528064 hasConcept C535046627 @default.
- W4378528064 hasConcept C71924100 @default.
- W4378528064 hasConcept C8891405 @default.
- W4378528064 hasConceptScore W4378528064C121608353 @default.
- W4378528064 hasConceptScore W4378528064C126322002 @default.
- W4378528064 hasConceptScore W4378528064C142724271 @default.
- W4378528064 hasConceptScore W4378528064C143998085 @default.