Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378839377> ?p ?o ?g. }
- W4378839377 endingPage "115281" @default.
- W4378839377 startingPage "115281" @default.
- W4378839377 abstract "Common genetic variants located in calcium channel genes are important markers of genetic susceptibility for bipolar disorder (BD). Previous clinical trials with Calcium Channel Blocker (CCB) medication improved mood stability for some BD patients. We hypothesize that manic patients who carried calcium channel risk variants would differentially benefit from treatment with CCBs. In this pilot study, 50 BD patients (Chinese: 39; US: 11) who were hospitalized for manic episodes were given add-on CCB treatment. We determined genotypes for each patient. There was a significant decrease in the Young Mania Rating Scale (YMRS) after add-on medication treatment. Of note, two intronic variants of the Calcium Voltage-Gated Channel Subunit Alpha1 B (CACNA1B) were associated with treatment outcomes for manic patients: rs2739258 and rs2739260. BD rs2739258/rs2739260 AG-allele carriers had a better treatment response with add-on CCB than those carrying the AA or GG genotypes by survival analysis. Although these findings did not pass multiple testing correction, this study suggests that single-nucleotide polymorphisms (SNPs) residing in calcium channel genes could be predictors for response to add-on CCB treatment of bipolar mania patients, and that calcium channel genes may be involved in treatment responses for BD." @default.
- W4378839377 created "2023-06-01" @default.
- W4378839377 creator A5003311118 @default.
- W4378839377 creator A5009911085 @default.
- W4378839377 creator A5016265908 @default.
- W4378839377 creator A5026817537 @default.
- W4378839377 creator A5029129951 @default.
- W4378839377 creator A5032831660 @default.
- W4378839377 creator A5040498986 @default.
- W4378839377 creator A5047098889 @default.
- W4378839377 creator A5049429175 @default.
- W4378839377 creator A5052676364 @default.
- W4378839377 creator A5054349197 @default.
- W4378839377 creator A5056248574 @default.
- W4378839377 creator A5068969552 @default.
- W4378839377 creator A5071158047 @default.
- W4378839377 creator A5076189264 @default.
- W4378839377 creator A5081822071 @default.
- W4378839377 creator A5085699056 @default.
- W4378839377 creator A5089219175 @default.
- W4378839377 date "2023-08-01" @default.
- W4378839377 modified "2023-10-01" @default.
- W4378839377 title "A pilot pharmacogenetic study of calcium channel blocker treatment of bipolar mania" @default.
- W4378839377 cites W184602233 @default.
- W4378839377 cites W185150343 @default.
- W4378839377 cites W1964928684 @default.
- W4378839377 cites W1970528899 @default.
- W4378839377 cites W1978473122 @default.
- W4378839377 cites W1983635763 @default.
- W4378839377 cites W1989524155 @default.
- W4378839377 cites W1993588417 @default.
- W4378839377 cites W2005654485 @default.
- W4378839377 cites W2009359462 @default.
- W4378839377 cites W2013616449 @default.
- W4378839377 cites W2013916220 @default.
- W4378839377 cites W2041388941 @default.
- W4378839377 cites W2041915741 @default.
- W4378839377 cites W2054968781 @default.
- W4378839377 cites W2058623711 @default.
- W4378839377 cites W2060187873 @default.
- W4378839377 cites W2062189135 @default.
- W4378839377 cites W2063280109 @default.
- W4378839377 cites W2064554173 @default.
- W4378839377 cites W2071927801 @default.
- W4378839377 cites W2090705041 @default.
- W4378839377 cites W2109488005 @default.
- W4378839377 cites W2127025881 @default.
- W4378839377 cites W2127442418 @default.
- W4378839377 cites W2136365449 @default.
- W4378839377 cites W2139852368 @default.
- W4378839377 cites W2167623599 @default.
- W4378839377 cites W2167659819 @default.
- W4378839377 cites W2170146596 @default.
- W4378839377 cites W2209106767 @default.
- W4378839377 cites W2344768536 @default.
- W4378839377 cites W2346688287 @default.
- W4378839377 cites W2400328894 @default.
- W4378839377 cites W241219989 @default.
- W4378839377 cites W2412736822 @default.
- W4378839377 cites W2510973425 @default.
- W4378839377 cites W2569020128 @default.
- W4378839377 cites W2745116209 @default.
- W4378839377 cites W2759086237 @default.
- W4378839377 cites W2888147011 @default.
- W4378839377 cites W2904884010 @default.
- W4378839377 cites W2909511188 @default.
- W4378839377 cites W2950375827 @default.
- W4378839377 cites W2954967623 @default.
- W4378839377 cites W2958615822 @default.
- W4378839377 cites W2980511836 @default.
- W4378839377 cites W2983765585 @default.
- W4378839377 cites W2995971356 @default.
- W4378839377 cites W2999532514 @default.
- W4378839377 cites W3008726958 @default.
- W4378839377 cites W3024219013 @default.
- W4378839377 cites W3036923110 @default.
- W4378839377 cites W3037932381 @default.
- W4378839377 cites W3106945714 @default.
- W4378839377 cites W3133859624 @default.
- W4378839377 cites W3162259891 @default.
- W4378839377 cites W4211069648 @default.
- W4378839377 cites W4225246927 @default.
- W4378839377 cites W4296759674 @default.
- W4378839377 doi "https://doi.org/10.1016/j.psychres.2023.115281" @default.
- W4378839377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37270865" @default.
- W4378839377 hasPublicationYear "2023" @default.
- W4378839377 type Work @default.
- W4378839377 citedByCount "0" @default.
- W4378839377 crossrefType "journal-article" @default.
- W4378839377 hasAuthorship W4378839377A5003311118 @default.
- W4378839377 hasAuthorship W4378839377A5009911085 @default.
- W4378839377 hasAuthorship W4378839377A5016265908 @default.
- W4378839377 hasAuthorship W4378839377A5026817537 @default.
- W4378839377 hasAuthorship W4378839377A5029129951 @default.
- W4378839377 hasAuthorship W4378839377A5032831660 @default.
- W4378839377 hasAuthorship W4378839377A5040498986 @default.
- W4378839377 hasAuthorship W4378839377A5047098889 @default.
- W4378839377 hasAuthorship W4378839377A5049429175 @default.