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• W4382182238 abstract "Glomerella leaf spot (GLS), caused by the fungal pathogen Colletotrichum fructicola, significantly threatens apple production. Some resistances to plant disease are mediated by the accumulation of nucleotide-binding site and leucine-rich repeat (NBS-LRR) proteins that are encoded by a major class of plant disease resistance genes (R genes). However, the R genes that confer resistance to GLS in apple remain largely unclear. Malus hupehensis YT521-B homology domain-containing protein 2 (MhYTP2) was identified as an N6 -methyladenosine RNA methylation (m6 A) modified RNA reader in our previous study. However, whether MhYTP2 binds to mRNAs without m6 A RNA modifications remains unknown. In this study, we discovered that MhYTP2 exerts both m6 A-dependent and -independent functions by analysing previously obtained RNA immunoprecipitation sequencing results. The overexpression of MhYTP2 significantly reduced the resistance of apple to GLS and down-regulated the transcript levels of some R genes whose transcripts do not contain m6 A modifications. Further analysis indicated that MhYTP2 binds to and reduces the stability of MdRGA2L mRNA. MdRGA2L positively regulates resistance to GLS by activating salicylic acid signalling. Our findings revealed that MhYTP2 plays an essential role in the regulation of resistance to GLS and identified a promising R gene, MdRGA2L, for use in developing apple cultivars with GLS resistance." @default.
• W4382182238 created "2023-06-28" @default.
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• W4382182238 date "2023-06-27" @default.
• W4382182238 modified "2023-10-17" @default.
• W4382182238 title "The <scp>m⁶A</scp> reader <scp>MhYTP2</scp> negatively modulates apple Glomerella leaf spot resistance by binding to and degrading <i>MdRGA2L</i> <scp>mRNA</scp>" @default.
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• W4382182238 doi "https://doi.org/10.1111/mpp.13370" @default.
• W4382182238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37366340" @default.
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