Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384816663> ?p ?o ?g. }
- W4384816663 endingPage "594" @default.
- W4384816663 startingPage "585" @default.
- W4384816663 abstract "Abstract Understanding kidney disease relies on defining the complexity of cell types and states, their associated molecular profiles and interactions within tissue neighbourhoods 1 . Here we applied multiple single-cell and single-nucleus assays (>400,000 nuclei or cells) and spatial imaging technologies to a broad spectrum of healthy reference kidneys (45 donors) and diseased kidneys (48 patients). This has provided a high-resolution cellular atlas of 51 main cell types, which include rare and previously undescribed cell populations. The multi-omic approach provides detailed transcriptomic profiles, regulatory factors and spatial localizations spanning the entire kidney. We also define 28 cellular states across nephron segments and interstitium that were altered in kidney injury, encompassing cycling, adaptive (successful or maladaptive repair), transitioning and degenerative states. Molecular signatures permitted the localization of these states within injury neighbourhoods using spatial transcriptomics, while large-scale 3D imaging analysis (around 1.2 million neighbourhoods) provided corresponding linkages to active immune responses. These analyses defined biological pathways that are relevant to injury time-course and niches, including signatures underlying epithelial repair that predicted maladaptive states associated with a decline in kidney function. This integrated multimodal spatial cell atlas of healthy and diseased human kidneys represents a comprehensive benchmark of cellular states, neighbourhoods, outcome-associated signatures and publicly available interactive visualizations." @default.
- W4384816663 created "2023-07-21" @default.
- W4384816663 creator A5000327891 @default.
- W4384816663 creator A5002734614 @default.
- W4384816663 creator A5003902741 @default.
- W4384816663 creator A5003987729 @default.
- W4384816663 creator A5004402387 @default.
- W4384816663 creator A5004691702 @default.
- W4384816663 creator A5004877715 @default.
- W4384816663 creator A5005612663 @default.
- W4384816663 creator A5005776943 @default.
- W4384816663 creator A5007149840 @default.
- W4384816663 creator A5007236534 @default.
- W4384816663 creator A5008309890 @default.
- W4384816663 creator A5008576700 @default.
- W4384816663 creator A5008584968 @default.
- W4384816663 creator A5009544182 @default.
- W4384816663 creator A5009678924 @default.
- W4384816663 creator A5010237445 @default.
- W4384816663 creator A5010862629 @default.
- W4384816663 creator A5011283199 @default.
- W4384816663 creator A5011697010 @default.
- W4384816663 creator A5011877804 @default.
- W4384816663 creator A5012394410 @default.
- W4384816663 creator A5013589380 @default.
- W4384816663 creator A5014244661 @default.
- W4384816663 creator A5014277270 @default.
- W4384816663 creator A5015941931 @default.
- W4384816663 creator A5017667237 @default.
- W4384816663 creator A5019161135 @default.
- W4384816663 creator A5020252530 @default.
- W4384816663 creator A5020881383 @default.
- W4384816663 creator A5021022035 @default.
- W4384816663 creator A5021094151 @default.
- W4384816663 creator A5021442302 @default.
- W4384816663 creator A5022177889 @default.
- W4384816663 creator A5023685291 @default.
- W4384816663 creator A5023791605 @default.
- W4384816663 creator A5023802736 @default.
- W4384816663 creator A5024249077 @default.
- W4384816663 creator A5024407391 @default.
- W4384816663 creator A5024546157 @default.
- W4384816663 creator A5025250742 @default.
- W4384816663 creator A5025452099 @default.
- W4384816663 creator A5025865647 @default.
- W4384816663 creator A5026812525 @default.
- W4384816663 creator A5027041943 @default.
- W4384816663 creator A5027583775 @default.
- W4384816663 creator A5028814633 @default.
- W4384816663 creator A5029430334 @default.
- W4384816663 creator A5029614311 @default.
- W4384816663 creator A5029617371 @default.
- W4384816663 creator A5029822854 @default.
- W4384816663 creator A5030215181 @default.
- W4384816663 creator A5030731012 @default.
- W4384816663 creator A5031218554 @default.
- W4384816663 creator A5031240083 @default.
- W4384816663 creator A5032334254 @default.
- W4384816663 creator A5032870005 @default.
- W4384816663 creator A5032911571 @default.
- W4384816663 creator A5033111028 @default.
- W4384816663 creator A5033212351 @default.
- W4384816663 creator A5033435676 @default.
- W4384816663 creator A5034164828 @default.
- W4384816663 creator A5034449272 @default.
- W4384816663 creator A5035673544 @default.
- W4384816663 creator A5035931728 @default.
- W4384816663 creator A5036258622 @default.
- W4384816663 creator A5037797105 @default.
- W4384816663 creator A5039241874 @default.
- W4384816663 creator A5040166190 @default.
- W4384816663 creator A5041269832 @default.
- W4384816663 creator A5041631465 @default.
- W4384816663 creator A5042356850 @default.
- W4384816663 creator A5042860576 @default.
- W4384816663 creator A5043195515 @default.
- W4384816663 creator A5043526876 @default.
- W4384816663 creator A5043634316 @default.
- W4384816663 creator A5044213727 @default.
- W4384816663 creator A5044783506 @default.
- W4384816663 creator A5044795540 @default.
- W4384816663 creator A5046575478 @default.
- W4384816663 creator A5046765991 @default.
- W4384816663 creator A5047698585 @default.
- W4384816663 creator A5048105597 @default.
- W4384816663 creator A5048144170 @default.
- W4384816663 creator A5048970531 @default.
- W4384816663 creator A5049789275 @default.
- W4384816663 creator A5049901757 @default.
- W4384816663 creator A5050246117 @default.
- W4384816663 creator A5050535039 @default.
- W4384816663 creator A5050645055 @default.
- W4384816663 creator A5050660002 @default.
- W4384816663 creator A5050736159 @default.
- W4384816663 creator A5051198855 @default.
- W4384816663 creator A5051378484 @default.
- W4384816663 creator A5051722726 @default.
- W4384816663 creator A5053291443 @default.