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• W4385543399 abstract "One of the distinguishing properties of hematopoietic stem cells is their ability to self-renew. Since self-renewal is important for the continuous replenishment of the hematopoietic stem cell pool, this property is often hijacked in blood cancers. Acute myeloid leukemia (AML) is believed to be arranged in a hierarchy, with self-renewing leukemia stem cells (LSCs) giving rise to the bulk tumor. Some of the earliest characterizations of LSCs were made in seminal studies that assessed the ability of prospectively isolated candidate AML stem cells to repopulate the entire heterogeneity of the tumor in mice. Further studies indicated that LSCs may be responsible for chemotherapy resistance and therefore act as a reservoir for secondary disease and leukemia relapse. In recent years, a number of studies have helped illuminate the complexity of clonality in bone marrow pathologies, including leukemias. Many features distinguishing LSCs from normal hematopoietic stem cells have been identified, and these studies have opened up diverse avenues for targeting LSCs, with an impact on the clinical management of AML patients. This review will discuss the role of self-renewal in AML and its implications, distinguishing characteristics between normal and leukemia stem cells, and opportunities for therapeutic targeting of AML LSCs." @default.
• W4385543399 created "2023-08-04" @default.
• W4385543399 creator A5009399465 @default.
• W4385543399 creator A5037540189 @default.
• W4385543399 date "2023-08-03" @default.
• W4385543399 modified "2023-10-18" @default.
• W4385543399 title "Therapeutic targeting of leukemia stem cells in acute myeloid leukemia" @default.
• W4385543399 cites W1876684013 @default.
• W4385543399 cites W1915661113 @default.
• W4385543399 cites W1967358345 @default.
• W4385543399 cites W1972902934 @default.
• W4385543399 cites W1974182237 @default.
• W4385543399 cites W1975730466 @default.
• W4385543399 cites W1976003274 @default.
• W4385543399 cites W1976021347 @default.
• W4385543399 cites W1978902427 @default.
• W4385543399 cites W1979421565 @default.
• W4385543399 cites W1981886750 @default.
• W4385543399 cites W1983641075 @default.
• W4385543399 cites W1985823023 @default.
• W4385543399 cites W1997412169 @default.
• W4385543399 cites W1998728654 @default.
• W4385543399 cites W1999008988 @default.
• W4385543399 cites W2002213310 @default.
• W4385543399 cites W2002772045 @default.
• W4385543399 cites W2003193974 @default.
• W4385543399 cites W2008630922 @default.
• W4385543399 cites W2008737258 @default.
• W4385543399 cites W2009397177 @default.
• W4385543399 cites W2009886857 @default.
• W4385543399 cites W2010519150 @default.
• W4385543399 cites W2011994267 @default.
• W4385543399 cites W2013971016 @default.
• W4385543399 cites W2015493376 @default.
• W4385543399 cites W2017098107 @default.
• W4385543399 cites W2018995141 @default.
• W4385543399 cites W2024763401 @default.
• W4385543399 cites W2026721712 @default.
• W4385543399 cites W2026990179 @default.
• W4385543399 cites W2028069487 @default.
• W4385543399 cites W2028824678 @default.
• W4385543399 cites W2034748898 @default.
• W4385543399 cites W2035197415 @default.
• W4385543399 cites W2041191257 @default.
• W4385543399 cites W2045662960 @default.
• W4385543399 cites W2046398696 @default.
• W4385543399 cites W2046540572 @default.
• W4385543399 cites W2047738133 @default.
• W4385543399 cites W2050249118 @default.
• W4385543399 cites W2054449135 @default.
• W4385543399 cites W2056598800 @default.
• W4385543399 cites W2058155210 @default.
• W4385543399 cites W2067272352 @default.
• W4385543399 cites W2067337288 @default.
• W4385543399 cites W2068141056 @default.
• W4385543399 cites W2069918359 @default.
• W4385543399 cites W2070387456 @default.
• W4385543399 cites W2074978329 @default.
• W4385543399 cites W2075306556 @default.
• W4385543399 cites W2075542228 @default.
• W4385543399 cites W2077813339 @default.
• W4385543399 cites W2078972833 @default.
• W4385543399 cites W2086149372 @default.
• W4385543399 cites W2090225072 @default.
• W4385543399 cites W2090982381 @default.
• W4385543399 cites W2093144236 @default.
• W4385543399 cites W2094727649 @default.
• W4385543399 cites W2097126393 @default.
• W4385543399 cites W2097519948 @default.
• W4385543399 cites W2102085111 @default.
• W4385543399 cites W2102304044 @default.
• W4385543399 cites W2103746815 @default.
• W4385543399 cites W2109336877 @default.
• W4385543399 cites W2124568469 @default.
• W4385543399 cites W2131072337 @default.
• W4385543399 cites W2131860315 @default.
• W4385543399 cites W2134987819 @default.
• W4385543399 cites W2135470678 @default.
• W4385543399 cites W2135835093 @default.
• W4385543399 cites W2137956382 @default.
• W4385543399 cites W2150443333 @default.
• W4385543399 cites W2153226086 @default.
• W4385543399 cites W2155507705 @default.
• W4385543399 cites W2161418339 @default.
• W4385543399 cites W2264873876 @default.
• W4385543399 cites W2337848504 @default.
• W4385543399 cites W2404149526 @default.
• W4385543399 cites W2404663151 @default.
• W4385543399 cites W2410306399 @default.
• W4385543399 cites W2414703178 @default.
• W4385543399 cites W2415007519 @default.
• W4385543399 cites W2419140434 @default.
• W4385543399 cites W2426586472 @default.
• W4385543399 cites W2461476252 @default.
• W4385543399 cites W2473447250 @default.
• W4385543399 cites W2488297479 @default.
• W4385543399 cites W2511116391 @default.
• W4385543399 cites W2520159331 @default.
• W4385543399 cites W2520704033 @default.
• W4385543399 cites W2523562238 @default.

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