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- W4386438198 abstract "Introduction Brain metastasis is a highly traumatic event in the progression of malignant tumors, often symbolizing higher mortality. Metabolic alterations are hallmarks of cancer, and the mask of lipid metabolic program rearrangement in cancer progression is gradually being unraveled.Areas covered In this work, we reviewed clinical and fundamental studies related to lipid expression and activity changes in brain metastases originating from lung, breast, and cutaneous melanomas, respectively. Novel roles of lipid metabolic reprogramming in the development of brain metastasis from malignant tumors were identified and its potential as a therapeutic target was evaluated. Published literature and clinical studies in databases consisting of PubMed, Embase, Scopus and www.ClinicalTrials.gov from 1990 to 2022 were searched.Expert opinion Lipid metabolic reprogramming in brain metastasis is involved in de novo lipid synthesis within low lipid availability environments, regulation of lipid uptake and storage, metabolic interactions between brain tumors and the brain microenvironment, and membrane lipid remodeling, in addition to being a second messenger for signal transduction. Although some lipid metabolism modulators work efficiently in preclinical models, there is still a long way to go from laboratory to clinic. This area of research holds assurance for the organ-targeted treatment of brain metastases through drug-regulated metabolic targets and dietary interventions." @default.
- W4386438198 created "2023-09-06" @default.
- W4386438198 creator A5013458957 @default.
- W4386438198 creator A5021269788 @default.
- W4386438198 creator A5030825527 @default.
- W4386438198 creator A5088291390 @default.
- W4386438198 date "2023-09-02" @default.
- W4386438198 modified "2023-10-15" @default.
- W4386438198 title "Lipid metabolism in malignant tumor brain metastasis: reprogramming and therapeutic potential" @default.
- W4386438198 cites W1520425169 @default.
- W4386438198 cites W1545954605 @default.
- W4386438198 cites W1602678530 @default.
- W4386438198 cites W1871335639 @default.
- W4386438198 cites W1958742527 @default.
- W4386438198 cites W1968343464 @default.
- W4386438198 cites W1968598018 @default.
- W4386438198 cites W1972254548 @default.
- W4386438198 cites W1978863320 @default.
- W4386438198 cites W1991279927 @default.
- W4386438198 cites W1991429659 @default.
- W4386438198 cites W1992477322 @default.
- W4386438198 cites W1992524428 @default.
- W4386438198 cites W1996838219 @default.
- W4386438198 cites W2000849147 @default.
- W4386438198 cites W2001548258 @default.
- W4386438198 cites W2006161539 @default.
- W4386438198 cites W2006221512 @default.
- W4386438198 cites W2009886463 @default.
- W4386438198 cites W2009949105 @default.
- W4386438198 cites W2015168005 @default.
- W4386438198 cites W2017399995 @default.
- W4386438198 cites W2020307093 @default.
- W4386438198 cites W2025994696 @default.
- W4386438198 cites W2033533993 @default.
- W4386438198 cites W2033958147 @default.
- W4386438198 cites W2038644613 @default.
- W4386438198 cites W2039202448 @default.
- W4386438198 cites W2039731227 @default.
- W4386438198 cites W2039843649 @default.
- W4386438198 cites W2041237929 @default.
- W4386438198 cites W2044515072 @default.
- W4386438198 cites W2047440678 @default.
- W4386438198 cites W2051823539 @default.
- W4386438198 cites W2054017411 @default.
- W4386438198 cites W2056040807 @default.
- W4386438198 cites W2057001750 @default.
- W4386438198 cites W2058725749 @default.
- W4386438198 cites W2060776420 @default.
- W4386438198 cites W2066772614 @default.
- W4386438198 cites W2066975798 @default.
- W4386438198 cites W2069782630 @default.
- W4386438198 cites W2073361691 @default.
- W4386438198 cites W2077328356 @default.
- W4386438198 cites W2078074220 @default.
- W4386438198 cites W2079711996 @default.
- W4386438198 cites W2089370460 @default.
- W4386438198 cites W2092474731 @default.
- W4386438198 cites W2093575933 @default.
- W4386438198 cites W2094513549 @default.
- W4386438198 cites W2098395271 @default.
- W4386438198 cites W2107845484 @default.
- W4386438198 cites W2110439798 @default.
- W4386438198 cites W2112347950 @default.
- W4386438198 cites W2114571023 @default.
- W4386438198 cites W2114805483 @default.
- W4386438198 cites W2115604279 @default.
- W4386438198 cites W2117284676 @default.
- W4386438198 cites W2118600577 @default.
- W4386438198 cites W2122767481 @default.
- W4386438198 cites W2125018169 @default.
- W4386438198 cites W2127229383 @default.
- W4386438198 cites W2132966617 @default.
- W4386438198 cites W2134917812 @default.
- W4386438198 cites W2138110344 @default.
- W4386438198 cites W2138331892 @default.
- W4386438198 cites W2138486337 @default.
- W4386438198 cites W2139126860 @default.
- W4386438198 cites W2140092500 @default.
- W4386438198 cites W2145045900 @default.
- W4386438198 cites W2153096480 @default.
- W4386438198 cites W2153178365 @default.
- W4386438198 cites W2162933629 @default.
- W4386438198 cites W2173224917 @default.
- W4386438198 cites W2234115940 @default.
- W4386438198 cites W2253833672 @default.
- W4386438198 cites W2258020595 @default.
- W4386438198 cites W2261881668 @default.
- W4386438198 cites W2293198017 @default.
- W4386438198 cites W2294507327 @default.
- W4386438198 cites W2346683950 @default.
- W4386438198 cites W2395360443 @default.
- W4386438198 cites W2410979882 @default.
- W4386438198 cites W2469482267 @default.
- W4386438198 cites W2469577546 @default.
- W4386438198 cites W2495185657 @default.
- W4386438198 cites W2521362603 @default.
- W4386438198 cites W2523687917 @default.
- W4386438198 cites W2528569964 @default.