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- W900702978 abstract "Abstract Accumulative indications propose that sperm DNA damage has a negative impact on male fertility. Therefore Cigarette smoking may be a possible source of chemicals capable of causing sperm DNA damage. The purpose of the present study was to evaluate the consequences of cigarette smoking on the sperm chromatin integrity of infertile patients undergoing IVF/ICSI therapy. Ejaculates from 795 patients of couples consulting for infertility were divided into smokers (n=340) and non-smokers (n=455). Sperm chromatin integrity was evaluated using Chromomycin A3 (CMA 3 ) and Terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) Assay methods. The smoking metabolite (Cotinine) was evaluated in seminal plasma by Enzyme Linked Immunosorbant Assay (ELISA) technique and Malondialdehyde (MDA) levels determined by chemical reactions. Results showed that, both parameters CMA 3 positive and TUNEL were significantly higher (p<0.001) in smokers (33.47±11.37%, 20.06±7.78%) than non- smokers (26.12 ±9.36%, and 12.68±5.43 respectively). Besides, both parameters were negatively associated with the sperm parameters. Moreover, the MDA (μM), and cotinine (ng/ml) levels were significantly higher (p<0.001) in smokers (7.97±1.56, 65.56 ±35.72) than that of non-smokers (5.45±1.50, 2.24±2.14, respectively). Likewise, these oxidative stress biomarkers were inversely (p<0.001) correlated with the sperm parameters. In conclusion, these outcomes propose that smoking may a risk factor of oxidative stress elevation and therefore deteriorate semen quality especially sperm nuclear integrity that disrupting sperm functions." @default.
- W900702978 created "2016-06-24" @default.
- W900702978 creator A5035761630 @default.
- W900702978 date "2014-05-06" @default.
- W900702978 modified "2023-09-26" @default.
- W900702978 title "Chromatin integrity in human ejaculate sperm of smokers and non-smokers patients and its relationship to seminal oxidative stress parameters" @default.
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- W900702978 doi "https://doi.org/10.12692/ijb/4.9.126-141" @default.
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