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- W4245016690 created "2022-05-12" @default.
- W4245016690 date "2003-03-12" @default.
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- W4245016690 title "and Var[νˆ ] = 4σ + l ) (l −2(1 + c . Similarly, when σˆ ≤ 0.04, νˆ = δˆ + σˆ − 0.04(c ) (7.12) is an estimate for the constant-scaled metric in accordance with FDA Guidance (2001) using a REML UN model. This estimate is asymptoti-cally normally distributed and unbiased with E[νˆ ] = δ +σ −σ − 0.04(c ) and Var[νˆ ] = 4σ . To assess PBE we ‘plug-in’ estimates of δ and the variance components and calculate the upper bound of an asymptotic 90% confidence interval. If this upper bound is below zero …" @default.
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