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- W4248662562 title "strate IBE the upper bound of a 90% confidence interval for the above aggregate metric must fall below 2.49. The required upper bound can be calculated in at least three different ways: (1) method-of-moments estimation with a Cornish-Fisher approx-imation (Hyslop et al., 2000; FDA Guidance, 2001), (2) bootstrapping (FDA Guidance, 1997), and (3) by asymptotic approximations to the mean and variance of ν and ν (Patterson, 2003; Patterson and Jones, 2002b,c). Method (1) derives from theory that …" @default.
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