Matches in Ubergraph for { <http://purl.obolibrary.org/obo/GO_0097527> ?p ?o ?g. }
- GO_0097527 RO_0002410 COB_0000037 @default.
- GO_0097527 RO_0002410 GO_0008150 @default.
- GO_0097527 RO_0002410 GO_0009987 @default.
- GO_0097527 RO_0002411 BFO_0000001 @default.
- GO_0097527 RO_0002411 BFO_0000003 @default.
- GO_0097527 RO_0002411 BFO_0000015 @default.
- GO_0097527 RO_0002411 COB_0000034 @default.
- GO_0097527 RO_0002411 COB_0000037 @default.
- GO_0097527 RO_0002411 GO_0008150 @default.
- GO_0097527 RO_0002411 GO_0009987 @default.
- GO_0097527 RO_0002418 BFO_0000001 @default.
- GO_0097527 RO_0002418 BFO_0000003 @default.
- GO_0097527 RO_0002418 BFO_0000015 @default.
- GO_0097527 RO_0002418 COB_0000034 @default.
- GO_0097527 RO_0002418 COB_0000037 @default.
- GO_0097527 RO_0002418 GO_0008150 @default.
- GO_0097527 RO_0002418 GO_0009987 @default.
- GO_0097527 RO_0002501 BFO_0000001 @default.
- GO_0097527 RO_0002501 BFO_0000003 @default.
- GO_0097527 RO_0002501 BFO_0000015 @default.
- GO_0097527 RO_0002501 COB_0000034 @default.
- GO_0097527 RO_0002501 COB_0000037 @default.
- GO_0097527 RO_0002501 GO_0008150 @default.
- GO_0097527 RO_0002501 GO_0009987 @default.
- GO_0097527 normalizedInformationContent "100" @default.
- GO_0097527 referenceCount "1" @default.
- GO_0097527 created_by "pr" @default.
- GO_0097527 creation_date "2013-11-05T14:17:28Z" @default.
- GO_0097527 hasExactSynonym "necroptosis signaling pathway" @default.
- GO_0097527 hasExactSynonym "necroptotic signal transduction" @default.
- GO_0097527 hasOBONamespace "biological_process" @default.
- GO_0097527 hasRelatedSynonym "necroptosis signaling" @default.
- GO_0097527 hasRelatedSynonym "necroptotic signalling pathway" @default.
- GO_0097527 id "GO:0097527" @default.
- GO_0097527 type Class @default.
- GO_0097527 comment "Gene products that may be annotated to this term include: 1) ligands such as TNF-alpha; 2) receptors such as TNFR (though care should be taken because TNF-alpha and TNFR may also be involved in non-necroptotic processes); 3) signaling molecules such as TNFR-associated death domain (TRADD), receptor-interacting protein kinase 1 (RIP1), cellular inhibitor of apoptosis 1 (cIAP1), cIAP2, TNFR-associated factor 2 (TRAF2) and TRAF5. Within the so-called complex I, RIP1 is polyubiquitinated by cIAPs, thereby providing a docking site for the recruitment of transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1), TAK1-binding protein 2 (TAB2) and TAB3 (which together deliver a pro-survival signal by activating the transcription factor NF-kB). In some pathophysiological and experimental settings, and in particular when caspase-8 is absent or when caspases are inhibited by pharmacological agents, cylindromatosis (CYLD)-deubiquitinated RIP1 engage in physical and functional interactions with its homolog RIP3, ultimately activating the execution of necrotic cell death. (The pathway downstream of RIPK3 remains largely unknown, although ROS generation, calcium overload, and the opening of the mitochondrial permeability transition pore have been implicated (PMID:22265414)). A necroptotic signaling pathway may also be induced by alkylating DNA damage (possibly by the overactivation of poly(ADP-ribose) polymerase 1, PARP1). This is sometimes referred to as PARP-dependent cell death or parthanatos; it is still being debated if it constitutes an independent cell death modality." @default.
- GO_0097527 isDefinedBy go.owl @default.
- GO_0097527 label "necroptotic signaling pathway" @default.
- GO_0097527 subClassOf B6920ac7afb02acf1e80948c00694057e @default.
- GO_0097527 subClassOf Bd3a30f4c3df390d843a6c1080a9ea86b @default.
- GO_0097527 subClassOf BFO_0000001 @default.
- GO_0097527 subClassOf BFO_0000003 @default.
- GO_0097527 subClassOf BFO_0000015 @default.
- GO_0097527 subClassOf COB_0000034 @default.
- GO_0097527 subClassOf COB_0000037 @default.
- GO_0097527 subClassOf GO_0007165 @default.
- GO_0097527 subClassOf GO_0008150 @default.
- GO_0097527 subClassOf GO_0009987 @default.
- GO_0097527 subClassOf GO_0050789 @default.
- GO_0097527 subClassOf GO_0050794 @default.
- GO_0097527 subClassOf GO_0065007 @default.
- GO_0097527 subClassOf GO_0097527 @default.
- GO_0097527 category BiologicalEntity @default.
- GO_0097527 category BiologicalProcess @default.
- GO_0097527 category BiologicalProcessOrActivity @default.
- GO_0097527 category Entity @default.
- GO_0097527 category NamedThing @default.
- GO_0097527 category Occurrent @default.
- GO_0097527 category OntologyClass @default.
- GO_0097527 category Pathway @default.
- GO_0097527 category PhysicalEssenceOrOccurrent @default.
- GO_0097527 category ThingWithTaxon @default.