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Matches in Ubergraph for { <http://purl.obolibrary.org/obo/HP_0002959> ?p ?o ?g. }

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HP_0002959 RO_0002323 OBA_VT0015074 @default.
HP_0002959 RO_0002323 OBA_VT1000783 @default.
HP_0002959 RO_0002323 PATO_0000001 @default.
HP_0002959 RO_0002323 PATO_0001241 @default.
HP_0002959 RO_0002323 PATO_0001509 @default.
HP_0002959 UPHENO_0000001 BFO_0000001 @default.
HP_0002959 UPHENO_0000001 BFO_0000002 @default.
HP_0002959 UPHENO_0000001 BFO_0000003 @default.
HP_0002959 UPHENO_0000001 BFO_0000004 @default.
HP_0002959 UPHENO_0000001 BFO_0000015 @default.
HP_0002959 UPHENO_0000001 BFO_0000040 @default.
HP_0002959 UPHENO_0000001 CARO_0000000 @default.
HP_0002959 UPHENO_0000001 CARO_0000006 @default.
HP_0002959 UPHENO_0000001 CARO_0001008 @default.
HP_0002959 UPHENO_0000001 CARO_0001010 @default.
HP_0002959 UPHENO_0000001 CARO_0010000 @default.
HP_0002959 UPHENO_0000001 CARO_0010004 @default.
HP_0002959 UPHENO_0000001 CARO_0020000 @default.
HP_0002959 UPHENO_0000001 CL_0000000 @default.
HP_0002959 UPHENO_0000001 CL_0000145 @default.
HP_0002959 UPHENO_0000001 CL_0000219 @default.
HP_0002959 UPHENO_0000001 CL_0000226 @default.
HP_0002959 UPHENO_0000001 CL_0000236 @default.
HP_0002959 UPHENO_0000001 CL_0000255 @default.
HP_0002959 UPHENO_0000001 CL_0000542 @default.
HP_0002959 UPHENO_0000001 CL_0000738 @default.
HP_0002959 UPHENO_0000001 CL_0000842 @default.
HP_0002959 UPHENO_0000001 CL_0000945 @default.
HP_0002959 UPHENO_0000001 CL_0000988 @default.
HP_0002959 UPHENO_0000001 CL_0002242 @default.
HP_0002959 UPHENO_0000001 COB_0000006 @default.
HP_0002959 UPHENO_0000001 COB_0000017 @default.
HP_0002959 UPHENO_0000001 COB_0000021 @default.
HP_0002959 UPHENO_0000001 COB_0000022 @default.
HP_0002959 UPHENO_0000001 COB_0000034 @default.
HP_0002959 UPHENO_0000001 COB_0000037 @default.
HP_0002959 UPHENO_0000001 COB_0000118 @default.
HP_0002959 UPHENO_0000001 FYPO_0000001 @default.
HP_0002959 UPHENO_0000001 GO_0002250 @default.
HP_0002959 UPHENO_0000001 GO_0002252 @default.
HP_0002959 UPHENO_0000001 GO_0002376 @default.
HP_0002959 UPHENO_0000001 GO_0002443 @default.
HP_0002959 UPHENO_0000001 GO_0005623 @default.
HP_0002959 UPHENO_0000001 GO_0006955 @default.
HP_0002959 UPHENO_0000001 GO_0008150 @default.
HP_0002959 UPHENO_0000001 GO_0008152 @default.
HP_0002959 UPHENO_0000001 GO_0050896 @default.
HP_0002959 UPHENO_0000001 NCBITaxon_1 @default.
HP_0002959 UPHENO_0000001 NCBITaxon_131567 @default.
HP_0002959 UPHENO_0000001 OBI_0100026 @default.
HP_0002959 UPHENO_0000001 PCO_0000031 @default.
HP_0002959 UPHENO_0000001 PR_000050567 @default.
HP_0002959 UPHENO_0000001 UBERON_0000061 @default.
HP_0002959 UPHENO_0000001 UBERON_0000465 @default.
HP_0002959 UPHENO_0000001 UBERON_0000467 @default.
HP_0002959 UPHENO_0000001 UBERON_0000468 @default.
HP_0002959 UPHENO_0000001 UBERON_0001062 @default.
HP_0002959 UPHENO_0000001 UBERON_0002193 @default.
HP_0002959 UPHENO_0000001 UBERON_0002390 @default.
HP_0002959 UPHENO_0000001 UBERON_0002405 @default.
HP_0002959 UPHENO_0000001 UBERON_0004120 @default.
HP_0002959 UPHENO_0000001 UBERON_0010000 @default.
HP_0002959 UPHENO_0000001 UBERON_0015203 @default.
HP_0002959 UPHENO_0000001 UBERON_0034923 @default.
HP_0002959 normalizedInformationContent "100" @default.
HP_0002959 referenceCount "1" @default.
HP_0002959 hasDbXref "UMLS:C1842528" @default.
HP_0002959 hasExactSynonym "Impaired B-lymphocyte isotype switching" @default.
HP_0002959 id "HP:0002959" @default.
HP_0002959 type Class @default.
HP_0002959 comment "The generation of the antibody repertoire requires two successive steps. The first is antigen- and T-cell-independent; it takes place in the fetal liver and the bone marrow. Immature B lymphocytes rearrange their immunoglobulin-gene variable segments (V segments), diversity segments (D segments) and joining segments (J segments), producing a functionally integrated VDJ segment linked to the mu constant region (C-mu), which determines the primary antibody repertoire composed of IgM antibodies. The second step is antigen- and T-cell-dependent and takes place in secondary lymphoid organs. After encountering antigen, B cells proliferate and form germinal centers. In this unique anatomic formation, two genetic events lead to generation of the secondary antibody repertoire: class-switch recombination (CSR) and somatic hypermutation (SHM). CSR of immunoglobulins occurs by a recombination process between two different switch regions (S regions) located upstream of each C region. Replacement of C-mu by a constant region of another class of immunoglobulin (C-gamma, C-alpha or C-epsilon) ensues and leads to the production of IgG, IgA or IgE." @default.
HP_0002959 isDefinedBy hp.owl @default.
HP_0002959 label "Impaired Ig class switch recombination" @default.
HP_0002959 subClassOf BFO_0000001 @default.
HP_0002959 subClassOf BFO_0000002 @default.
HP_0002959 subClassOf BFO_0000020 @default.
HP_0002959 subClassOf COB_0000502 @default.
HP_0002959 subClassOf FBcv_0000000 @default.
HP_0002959 subClassOf FBcv_0000013 @default.
HP_0002959 subClassOf FBcv_0000347 @default.
HP_0002959 subClassOf FBcv_0000807 @default.
HP_0002959 subClassOf FBcv_0001347 @default.
HP_0002959 subClassOf FYPO_0000001 @default.
HP_0002959 subClassOf FYPO_0000300 @default.
HP_0002959 subClassOf FYPO_0001985 @default.
HP_0002959 subClassOf FYPO_0005447 @default.
HP_0002959 subClassOf HP_0000001 @default.
HP_0002959 subClassOf HP_0000118 @default.
HP_0002959 subClassOf HP_0001871 @default.
HP_0002959 subClassOf HP_0001939 @default.
HP_0002959 subClassOf HP_0002715 @default.
HP_0002959 subClassOf HP_0002959 @default.
HP_0002959 subClassOf HP_0005372 @default.
HP_0002959 subClassOf HP_0010978 @default.
HP_0002959 subClassOf HP_0011017 @default.
HP_0002959 subClassOf HP_0025354 @default.
HP_0002959 subClassOf HP_0031409 @default.
HP_0002959 subClassOf HP_0033796 @default.
HP_0002959 subClassOf MP_0000001 @default.
HP_0002959 subClassOf MP_0001545 @default.

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