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- MI_0208 isDefinedBy "A genetic interaction refers to an unexpected phenotype not easily explained by combining the effects of individual genetic variants (7)." @default.
- MI_0208 isDefinedBy "A quantitative genetic interaction definition has two components: a quantitative phenotypic measure and a neutrality function that predicts the phenotype of an organism carrying two noninteracting mutations. Interaction is then defined by deviation of a double-mutant organism's phenotype from the expected neutral phenotype." @default.
- MI_0208 isDefinedBy "More generally, a genetic interaction can be defined as the difference between an experimentally measured double-mutant phenotype and an expected double-mutant phenotype, the latter of which is predicted from the combination of the single-mutant effects, assuming the mutations act independently." @default.
- MI_0208 isDefinedBy "Two genes A and B 'genetically interact' when the phenotype generated as the result of mutations in both genes (double mutant ab) is unexpectedly not just a combination of the phenotypes of the two single mutants a and b." @default.
- MI_0795 isDefinedBy "A, B, and the AB combination all have the same effect on the WT background (2 inequalities)." @default.
- MI_0795 isDefinedBy "Another subtype of alleviating interaction, 'coequal' interaction, is defined by single- and double-mutant strains that exhibit fitness values that are indistinguishable from one another (19)." @default.
- MI_0795 isDefinedBy "Lastly, we observed ten gene pairs for which the MMS sensitivity of the single- and double-deletion strains was statistically indistinguishable (Sxy = Sx = Sy). These interactions, which we call ‘coequal’, are related to‘complementary gene action’, ‘complementary epistasis’ or ‘asynthetic’ relationship types that have been previously described18,30,31." @default.
- MI_2394 isDefinedBy "Negative genetic interactions describe double mutants whose phenotype is stronger than expected (66, 77) (Figure 1b)." @default.
- MI_2394 isDefinedBy "Negative interactions (also called aggravating or synergistic interactions) describe double mutants exhibiting a more severe phenotype than expected, such as synthetic sickness or synthetic lethality (35, 49) (Figure 2a)." @default.
- MI_2395 isDefinedBy "Positive genetic interactions define double mutants whose phenotype is less severe than expected based on single-mutant phenotypes (30, 66, 87) (Figure 1c,d)." @default.
- MI_2395 isDefinedBy "Positive interactions describe double mutants exhibiting a less severe phenotype than expected from the multiplicative model. Positive interactions have also been referred to as alleviating or epistatic interactions." @default.