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- FBcv_0003009 IAO_0000115 "Sequence change caused by the cleavage of specific DNA sequences by transcription activator-like effector nucleases (TALENs). TALEN proteins comprise a DNA binding domain fused to the catalytic domain of the FokI endonuclease. The DNA binding domain contains a repetitive region within the middle of the protein, consisting of tandem repeats of 34 amino acid segments, with each of these segments recognizing a single base pair. The specificity of the binding is determined by two hypervariable amino acids in positions 12 and 13 (repeat-variable diresidues). Cleavage requires dimerization of FokI. The endonuclease is directed to a target region by a pair of TALENs which bind to adjacent sequences separated by a spacer region, allowing dimerization and promoting cleavage." @default.
- FBcv_0003009 contributor 0000-0001-5948-3092 @default.
- FBcv_0003009 date "2014-03-27T11:07:29.000Z" @default.
- FBcv_0003009 normalizedInformationContent "100" @default.
- FBcv_0003009 referenceCount "1" @default.
- FBcv_0003009 hasExactSynonym "change induced by TALE endonuclease cleavage" @default.
- FBcv_0003009 hasOBONamespace "origin_of_mutation" @default.
- FBcv_0003009 hasRelatedSynonym "TALE endonuclease" @default.
- FBcv_0003009 id "FBcv:0003009" @default.
- FBcv_0003009 type Class @default.
- FBcv_0003009 isDefinedBy fbcv.owl @default.
- FBcv_0003009 label "TALEN" @default.
- FBcv_0003009 subClassOf FBcv_0000000 @default.
- FBcv_0003009 subClassOf FBcv_0000013 @default.
- FBcv_0003009 subClassOf FBcv_0000452 @default.
- FBcv_0003009 subClassOf FBcv_0000807 @default.
- FBcv_0003009 subClassOf FBcv_0003007 @default.
- FBcv_0003009 subClassOf FBcv_0003009 @default.