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- FBcv_0003239 IAO_0000115 "Sequence change caused by the cleavage of specific DNA sequences by zinc finger nucleases (ZFNs). ZFN proteins comprise a DNA binding domain linked to the DNA cleavage domain of FokI endonuclease. The DNA binding domain is composed of three Cys2His2 zinc fingers, with each zinc finger contacting three consecutive base pairs of DNA. The specificity of the binding is determined by the sequence of the three-zinc finger DNA binding domain, which recognizes a 9 base pair sequence. Cleavage requires dimerization of FokI. The endonuclease is directed to a target region by a pair of ZFNs which bind to sequences in close proximity, allowing dimerization and promoting cleavage." @default.
- FBcv_0003239 contributor 0000-0001-5948-3092 @default.
- FBcv_0003239 date "2016-04-06T10:22:52.000Z" @default.
- FBcv_0003239 normalizedInformationContent "100" @default.
- FBcv_0003239 referenceCount "1" @default.
- FBcv_0003239 hasExactSynonym "change induced by zinc finger nuclease-mediated cleavage" @default.
- FBcv_0003239 hasOBONamespace "origin_of_mutation" @default.
- FBcv_0003239 hasRelatedSynonym "zinc finger nuclease" @default.
- FBcv_0003239 id "FBcv:0003239" @default.
- FBcv_0003239 inSubset camcur @default.
- FBcv_0003239 type Class @default.
- FBcv_0003239 isDefinedBy fbcv.owl @default.
- FBcv_0003239 label "ZFN" @default.
- FBcv_0003239 subClassOf FBcv_0000000 @default.
- FBcv_0003239 subClassOf FBcv_0000013 @default.
- FBcv_0003239 subClassOf FBcv_0000452 @default.
- FBcv_0003239 subClassOf FBcv_0000807 @default.
- FBcv_0003239 subClassOf FBcv_0003007 @default.
- FBcv_0003239 subClassOf FBcv_0003239 @default.