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- FBcv_0005069 IAO_0000115 "An enhancer trap cassette is designed to report or utilize the expression of endogenous enhancer elements upon integration of the cassette into the genome. The basic components of an enhancer trap cassette are a minimal promoter element fused upstream of a gene. Upon integration into the genome, a neighboring genomic enhancer may activate expression of the gene encoded by the enhancer trap cassette. Depending on the nature of this gene, the insertion may directly report the expression pattern of the 'trapped' enhancer (e.g. if the gene encodes a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest (e.g. if the gene encodes a driver that forms part of a binary expression system). An enhancer trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. An enhancer trap insertion can be mutagenic, disrupting the function of an endogenous locus, depending on the particular insertion site." @default.
- FBcv_0005069 contributor 0000-0002-0027-0858 @default.
- FBcv_0005069 date "2017-12-13T13:17:30.000Z" @default.
- FBcv_0005069 normalizedInformationContent "100" @default.
- FBcv_0005069 referenceCount "1" @default.
- FBcv_0005069 hasDbXref "SO:0001479" @default.
- FBcv_0005069 hasOBONamespace "experimental_tool_descriptor" @default.
- FBcv_0005069 hasRelatedSynonym "enhancer detection tool" @default.
- FBcv_0005069 id "FBcv:0005069" @default.
- FBcv_0005069 type Class @default.
- FBcv_0005069 isDefinedBy fbcv.owl @default.
- FBcv_0005069 label "enhancer trap" @default.
- FBcv_0005069 subClassOf FBcv_0000000 @default.
- FBcv_0005069 subClassOf FBcv_0000013 @default.
- FBcv_0005069 subClassOf FBcv_0005001 @default.
- FBcv_0005069 subClassOf FBcv_0005068 @default.
- FBcv_0005069 subClassOf FBcv_0005069 @default.