Matches in Ubergraph for { <http://purl.obolibrary.org/obo/FBcv_0005074> ?p ?o ?g. }
Showing items 1 to 15 of
15
with 100 items per page.
- FBcv_0005074 IAO_0000115 "The basic components of a misexpression element are an enhancer sequence plus a minimal promoter. Upon integration into the genome, this element can activate expression of nearby endogenous loci. Typically, constructs containing misexpression elements are designed to insert at or near the 5' end of a gene, such that expression from the promoter within the misexpression element drives overexpression of the endogenous locus and causes a gain-of-function phenotype. However, if the insertion is within a locus, a truncated product may be produced, while an insertion in the opposite orientation to that of the direction of transcription of the endogenous locus can result in the production of an antisense transcript. If the enhancer present in the misexpression element forms part of a binary expression system, the misexpression pattern of the endogenous gene is controlled by combining the misexpression element insertion with a driver expressed in the desired temporal and spatial pattern." @default.
- FBcv_0005074 contributor 0000-0002-0027-0858 @default.
- FBcv_0005074 date "2017-12-13T13:17:30.000Z" @default.
- FBcv_0005074 normalizedInformationContent "100" @default.
- FBcv_0005074 referenceCount "1" @default.
- FBcv_0005074 hasOBONamespace "experimental_tool_descriptor" @default.
- FBcv_0005074 id "FBcv:0005074" @default.
- FBcv_0005074 type Class @default.
- FBcv_0005074 isDefinedBy fbcv.owl @default.
- FBcv_0005074 label "misexpression element" @default.
- FBcv_0005074 subClassOf FBcv_0000000 @default.
- FBcv_0005074 subClassOf FBcv_0000013 @default.
- FBcv_0005074 subClassOf FBcv_0005001 @default.
- FBcv_0005074 subClassOf FBcv_0005068 @default.
- FBcv_0005074 subClassOf FBcv_0005074 @default.