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- MI_2323 IAO_0000115 "KISS (KInase Substrate Sensor) is a protein complementation technology that allows in situ analysis of protein-protein interactions in intact mammalian cells. In this method, which is derived from MAPPIT (mammalian protein-protein interaction trap), the bait protein is coupled to the kinase domain of TYK2, while the prey protein is fused to a fragment of the gp130 cytokine receptor chain. Bait and prey interaction leads to phosphorylation of the gp130 anchor by TYK2, followed by recruitment and activation of STAT3, resulting in transcription of a STAT3-dependent reporter system. This approach enables the identification of interactions between proteins, including transmembrane and cytosolic proteins, and their modulation in response to physiological or pharmacological challenges." @default.
- MI_2323 normalizedInformationContent "100" @default.
- MI_2323 referenceCount "1" @default.
- MI_2323 created_by "pporras" @default.
- MI_2323 creation_date "2019-04-02T09:58:26Z" @default.
- MI_2323 hasExactSynonym "KISS" @default.
- MI_2323 hasExactSynonym "kinase substrate sensor" @default.
- MI_2323 hasExactSynonym "kiss" @default.
- MI_2323 hasOBONamespace "PSI-MI" @default.
- MI_2323 id "MI:2323" @default.
- MI_2323 inSubset PSI-MI_slim @default.
- MI_2323 type Class @default.
- MI_2323 isDefinedBy mi.owl @default.
- MI_2323 label "kiss" @default.
- MI_2323 subClassOf MI_0000 @default.
- MI_2323 subClassOf MI_0001 @default.
- MI_2323 subClassOf MI_0045 @default.
- MI_2323 subClassOf MI_0090 @default.
- MI_2323 subClassOf MI_2323 @default.