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- NCIT_C100099 IAO_0000115 "A cancer vaccine comprised of nine class I major histocompatibility complex (MHC)-restricted breast cancer associated peptides, the tetanus toxoid helper peptide and the Toll-like receptor 3 (TLR3) agonist poly ICLC, with potential immunostimulatory and antineoplastic activities. The nine peptides derived from six cancer associated proteins are epidermal growth factor receptor 2 (HER2/neu), carcinoembryonic antigen (CEA) and four cancer/testis antigens (CTAs: MAGE-A1, -A3, -A10, and NY-ESO-1). Vaccination with this vaccine may elicit a specific cytotoxic T-lymphocyte (CTL) response against cells overexpressing these tumor associated antigens (TAAs). As a nonspecific T-helper epitope, tetanus toxoid helper peptide binds to class II MHC and results in long-term immunopotentiation by increasing the helper T-cell response. Poly ICLC, the double-stranded RNA molecules of polyinosinic-polycytidylic acid stabilized with poly L-lysine in carboxymethylcellulose, binds to TLR3 and induces the release of cytokines which may help boost the immune response against the TAAs." @default.
- NCIT_C100099 NCIT_A7 NCIT_C104498 @default.
- NCIT_C100099 NCIT_A7 NCIT_C104511 @default.
- NCIT_C100099 NCIT_A7 NCIT_C16384 @default.
- NCIT_C100099 NCIT_A7 NCIT_C17319 @default.
- NCIT_C100099 NCIT_A7 NCIT_C17513 @default.
- NCIT_C100099 NCIT_A7 NCIT_C39286 @default.
- NCIT_C100099 NCIT_NHC0 "C100099" @default.
- NCIT_C100099 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C100099 NCIT_P107 "Synthetic Breast Cancer Peptides-Tetanus Toxoid-Poly ICLC Vaccine" @default.
- NCIT_C100099 NCIT_P108 "Synthetic Breast Cancer Peptides-Tetanus Toxoid-Poly ICLC Vaccine" @default.
- NCIT_C100099 NCIT_P208 "CL434402" @default.
- NCIT_C100099 NCIT_P322 "CTRP" @default.
- NCIT_C100099 NCIT_P329 "726670" @default.
- NCIT_C100099 NCIT_P330 "726670" @default.
- NCIT_C100099 NCIT_P399 "726670" @default.
- NCIT_C100099 normalizedInformationContent "100" @default.
- NCIT_C100099 referenceCount "1" @default.
- NCIT_C100099 hasExactSynonym "Synthetic Breast Cancer Peptides-Tetanus Toxoid-Poly ICLC Vaccine" @default.
- NCIT_C100099 inSubset NCIT_C116977 @default.
- NCIT_C100099 inSubset NCIT_C116978 @default.
- NCIT_C100099 inSubset NCIT_C128784 @default.
- NCIT_C100099 inSubset NCIT_C176424 @default.
- NCIT_C100099 type Class @default.
- NCIT_C100099 isDefinedBy ncit.owl @default.
- NCIT_C100099 label "Synthetic Breast Cancer Peptides-Tetanus Toxoid-Poly ICLC Vaccine" @default.
- NCIT_C100099 subClassOf NCIT_C100099 @default.
- NCIT_C100099 subClassOf NCIT_C129820 @default.
- NCIT_C100099 subClassOf NCIT_C1663 @default.
- NCIT_C100099 subClassOf NCIT_C1908 @default.
- NCIT_C100099 subClassOf NCIT_C1909 @default.
- NCIT_C100099 subClassOf NCIT_C274 @default.
- NCIT_C100099 subClassOf NCIT_C307 @default.
- NCIT_C100099 subClassOf NCIT_C308 @default.
- NCIT_C100099 subClassOf NCIT_C923 @default.