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- NCIT_C1003 IAO_0000115 "An antineoplastic antibiotic of macrocyclic benzoquinone isolated from the bacterial genus Streptomyces. Ansamycin antibiotics bind to and inhibit the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins and the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells." @default.
- NCIT_C1003 NCIT_NHC0 "C1003" @default.
- NCIT_C1003 NCIT_P106 "Chemical Viewed Functionally" @default.
- NCIT_C1003 NCIT_P108 "Ansamycin Antineoplastic Antibiotic" @default.
- NCIT_C1003 NCIT_P207 "C0051936" @default.
- NCIT_C1003 NCIT_P325 "An anticancer drug that belongs to the family of drugs called antineoplastic antibiotics." @default.
- NCIT_C1003 NCIT_P366 "Ansamycin_Antineoplastic_Antibiotic" @default.
- NCIT_C1003 NCIT_P368 "CHEBI:22565" @default.
- NCIT_C1003 normalizedInformationContent "83.556969816060246" @default.
- NCIT_C1003 referenceCount "12" @default.
- NCIT_C1003 hasExactSynonym "Ansamycin Antibiotics" @default.
- NCIT_C1003 hasExactSynonym "Ansamycin Antineoplastic Antibiotic" @default.
- NCIT_C1003 hasExactSynonym "Ansamycins" @default.
- NCIT_C1003 hasExactSynonym "ansamycin" @default.
- NCIT_C1003 type Class @default.
- NCIT_C1003 isDefinedBy ncit.owl @default.
- NCIT_C1003 label "Ansamycin Antineoplastic Antibiotic" @default.
- NCIT_C1003 subClassOf NCIT_C1003 @default.
- NCIT_C1003 subClassOf NCIT_C129824 @default.
- NCIT_C1003 subClassOf NCIT_C186664 @default.
- NCIT_C1003 subClassOf NCIT_C1908 @default.
- NCIT_C1003 subClassOf NCIT_C1909 @default.
- NCIT_C1003 subClassOf NCIT_C2189 @default.
- NCIT_C1003 subClassOf NCIT_C259 @default.
- NCIT_C1003 subClassOf NCIT_C274 @default.
- NCIT_C1003 subClassOf NCIT_C74526 @default.