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- NCIT_C101132 IAO_0000115 "An active metabolite of NV-128, a novel flavonoid small molecule inhibitor of the mammalian Target of Rapamycin (mTOR), with potential antineoplastic activity. Upon administration, mTOR1/2 Kinase inhibitor ME-344 downregulates the PIK3/AKT/mTOR pathway and results in chromatin condensation in the absence of caspase activation. Consequently, this agent induces caspase-independent cell death in tumor cells with a de-regulated PIK3/AKT/mTOR pathway or chemotherapeutic resistant cells." @default.
- NCIT_C101132 NCIT_A32 NCIT_C1909 @default.
- NCIT_C101132 NCIT_NHC0 "C101132" @default.
- NCIT_C101132 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101132 NCIT_P108 "mTOR1/2 Kinase Inhibitor ME-344" @default.
- NCIT_C101132 NCIT_P207 "C3639999" @default.
- NCIT_C101132 NCIT_P210 "1374524-68-1" @default.
- NCIT_C101132 NCIT_P319 "843G0TDV51" @default.
- NCIT_C101132 NCIT_P322 "FDA" @default.
- NCIT_C101132 NCIT_P322 "GDC" @default.
- NCIT_C101132 NCIT_P329 "728650" @default.
- NCIT_C101132 NCIT_P330 "728650" @default.
- NCIT_C101132 NCIT_P375 "mTOR1/2 Kinase Inhibitor ME-344" @default.
- NCIT_C101132 NCIT_P399 "728650" @default.
- NCIT_C101132 normalizedInformationContent "100" @default.
- NCIT_C101132 referenceCount "1" @default.
- NCIT_C101132 hasExactSynonym "ME-344" @default.
- NCIT_C101132 hasExactSynonym "mTOR1/2 Kinase Inhibitor ME-344" @default.
- NCIT_C101132 inSubset NCIT_C128784 @default.
- NCIT_C101132 inSubset NCIT_C157711 @default.
- NCIT_C101132 inSubset NCIT_C157712 @default.
- NCIT_C101132 inSubset NCIT_C176424 @default.
- NCIT_C101132 inSubset NCIT_C177537 @default.
- NCIT_C101132 inSubset NCIT_C63923 @default.
- NCIT_C101132 type Class @default.
- NCIT_C101132 isDefinedBy ncit.owl @default.
- NCIT_C101132 label "mTOR1/2 Kinase Inhibitor ME-344" @default.
- NCIT_C101132 subClassOf NCIT_C101132 @default.
- NCIT_C101132 subClassOf NCIT_C129824 @default.
- NCIT_C101132 subClassOf NCIT_C129825 @default.
- NCIT_C101132 subClassOf NCIT_C1404 @default.
- NCIT_C101132 subClassOf NCIT_C163758 @default.
- NCIT_C101132 subClassOf NCIT_C1742 @default.
- NCIT_C101132 subClassOf NCIT_C1908 @default.
- NCIT_C101132 subClassOf NCIT_C1909 @default.
- NCIT_C101132 subClassOf NCIT_C2189 @default.
- NCIT_C101132 subClassOf NCIT_C2201 @default.
- NCIT_C101132 subClassOf NCIT_C274 @default.
- NCIT_C101132 subClassOf NCIT_C471 @default.
- NCIT_C101132 subClassOf NCIT_C61074 @default.