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- NCIT_C101133 IAO_0000115 "A radioimmunoconjugate comprised of the recombinant humanized monoclonal antibody J591 against prostate-specific membrane antigen (PSMA) conjugated to chelator desferrioxamine B (DFO-B) and labeled with the radioisotope zirconium Zr 89 with potential imaging property used in positron emission tomography (PET) imaging. Upon administration of zirconium Zr 89 desferrioxamine B monoclonal antibody huJ591, the antibody moiety binds to the extracellular domain of PSMA, and the radioisotope moiety may be detected using PET, thereby allowing the imaging and quantification of PSMA-expressing tumor cells. PSMA, or folate hydrolase, is a cell surface peptidase highly expressed by malignant prostate epithelial cells and vascular endothelial cells of numerous solid tumor malignancies. In addition, upon PET imaging this agent provides high tumor:background tissue ratios." @default.
- NCIT_C101133 NCIT_A7 NCIT_C17796 @default.
- NCIT_C101133 NCIT_NHC0 "C101133" @default.
- NCIT_C101133 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C101133 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C101133 NCIT_P107 "Zirconium Zr 89 Desferrioxamine B Monoclonal Antibody huJ591" @default.
- NCIT_C101133 NCIT_P108 "Zirconium Zr 89 Desferrioxamine B Monoclonal Antibody huJ591" @default.
- NCIT_C101133 NCIT_P208 "CL433986" @default.
- NCIT_C101133 NCIT_P322 "CTRP" @default.
- NCIT_C101133 NCIT_P329 "728672" @default.
- NCIT_C101133 NCIT_P330 "728672" @default.
- NCIT_C101133 NCIT_P399 "728672" @default.
- NCIT_C101133 normalizedInformationContent "100" @default.
- NCIT_C101133 referenceCount "1" @default.
- NCIT_C101133 hasExactSynonym "89Zr-DFO-huJ591" @default.
- NCIT_C101133 hasExactSynonym "Zirconium Zr 89 Desferrioxamine B Monoclonal Antibody huJ591" @default.
- NCIT_C101133 inSubset NCIT_C116977 @default.
- NCIT_C101133 inSubset NCIT_C116978 @default.
- NCIT_C101133 inSubset NCIT_C176424 @default.
- NCIT_C101133 type Class @default.
- NCIT_C101133 isDefinedBy ncit.owl @default.
- NCIT_C101133 label "Zirconium Zr 89 Desferrioxamine B Monoclonal Antibody huJ591" @default.
- NCIT_C101133 subClassOf NCIT_C101133 @default.
- NCIT_C101133 subClassOf NCIT_C1446 @default.
- NCIT_C101133 subClassOf NCIT_C1511 @default.
- NCIT_C101133 subClassOf NCIT_C1512 @default.
- NCIT_C101133 subClassOf NCIT_C1908 @default.
- NCIT_C101133 subClassOf NCIT_C1909 @default.
- NCIT_C101133 subClassOf NCIT_C2124 @default.
- NCIT_C101133 subClassOf NCIT_C307 @default.
- NCIT_C101133 subClassOf NCIT_C308 @default.