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- NCIT_C101258 IAO_0000115 "Allogeneic T-lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD3zeta-4-1BB-expressing allogeneic T-lymphocyte cells direct the T-lymphocytes to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19 and the inclusion of this signaling domain may increase the antitumor activity compared to the inclusion of the CD3-zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies." @default.
- NCIT_C101258 NCIT_A7 NCIT_C38894 @default.
- NCIT_C101258 NCIT_NHC0 "C101258" @default.
- NCIT_C101258 NCIT_P106 "Cell" @default.
- NCIT_C101258 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101258 NCIT_P107 "CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells" @default.
- NCIT_C101258 NCIT_P108 "CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells" @default.
- NCIT_C101258 NCIT_P208 "CL435506" @default.
- NCIT_C101258 NCIT_P322 "CTRP" @default.
- NCIT_C101258 NCIT_P329 "729149" @default.
- NCIT_C101258 NCIT_P330 "729149" @default.
- NCIT_C101258 NCIT_P399 "729149" @default.
- NCIT_C101258 normalizedInformationContent "100" @default.
- NCIT_C101258 referenceCount "1" @default.
- NCIT_C101258 hasExactSynonym "CART-19 Cells" @default.
- NCIT_C101258 hasExactSynonym "CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells" @default.
- NCIT_C101258 inSubset NCIT_C116977 @default.
- NCIT_C101258 inSubset NCIT_C116978 @default.
- NCIT_C101258 inSubset NCIT_C128784 @default.
- NCIT_C101258 inSubset NCIT_C176424 @default.
- NCIT_C101258 type Class @default.
- NCIT_C101258 isDefinedBy ncit.owl @default.
- NCIT_C101258 label "CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells" @default.
- NCIT_C101258 subClassOf NCIT_C101258 @default.
- NCIT_C101258 subClassOf NCIT_C129820 @default.
- NCIT_C101258 subClassOf NCIT_C129821 @default.
- NCIT_C101258 subClassOf NCIT_C129826 @default.
- NCIT_C101258 subClassOf NCIT_C137999 @default.
- NCIT_C101258 subClassOf NCIT_C142078 @default.
- NCIT_C101258 subClassOf NCIT_C154231 @default.
- NCIT_C101258 subClassOf NCIT_C176018 @default.
- NCIT_C101258 subClassOf NCIT_C1908 @default.
- NCIT_C101258 subClassOf NCIT_C1909 @default.
- NCIT_C101258 subClassOf NCIT_C1962 @default.
- NCIT_C101258 subClassOf NCIT_C200765 @default.
- NCIT_C101258 subClassOf NCIT_C274 @default.
- NCIT_C101258 subClassOf NCIT_C28676 @default.
- NCIT_C101258 subClassOf NCIT_C307 @default.
- NCIT_C101258 subClassOf NCIT_C308 @default.