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- NCIT_C101259 IAO_0000115 "A pegylated, recombinant form of L-asparaginase derived from the bacterium Erwinia chrysanthemi (mPEG-R-Crisantaspase), with potential antineoplastic activity. Upon intravenous administration of pegylated recombinant L-asparaginase Erwinia chrysanthemi, asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting cancer cells of asparagine thus blocking protein synthesis and tumor cell proliferation. Asparagine is critical to protein synthesis in cancer cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Compared to other available Erwinia chrysanthemi derived L-asparaginase agents, the pegylated form is longer acting and less immunogenic." @default.
- NCIT_C101259 NCIT_NHC0 "C101259" @default.
- NCIT_C101259 NCIT_P106 "Enzyme" @default.
- NCIT_C101259 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101259 NCIT_P108 "Pegylated Recombinant L-asparaginase Erwinia chrysanthemi" @default.
- NCIT_C101259 NCIT_P200 "C177280" @default.
- NCIT_C101259 NCIT_P310 "Retired_Concept" @default.
- NCIT_C101259 NCIT_P98 "Mon Jan 03 13:01:43 EST 2022 - See 'Pegcrisantaspase(C170297)'" @default.
- NCIT_C101259 normalizedInformationContent "100" @default.
- NCIT_C101259 referenceCount "1" @default.
- NCIT_C101259 hasExactSynonym "Pegylated Recombinant L-asparaginase Erwinia chrysanthemi" @default.
- NCIT_C101259 type Class @default.
- NCIT_C101259 isDefinedBy ncit.owl @default.
- NCIT_C101259 label "Pegylated Recombinant L-asparaginase Erwinia chrysanthemi" @default.
- NCIT_C101259 subClassOf NCIT_C101259 @default.
- NCIT_C101259 subClassOf NCIT_C192094 @default.
- NCIT_C101259 subClassOf NCIT_C28428 @default.
- NCIT_C101259 deprecated "true" @default.