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- NCIT_C101367 IAO_0000115 "A recombinant anaerobic bacterium, Bifidobacterium longum, encoding the cytosine deaminase (CD) gene with potential antineoplastic adjuvant activity. Upon injection, the CD-expressing bifidobacterium preferentially localizes and grows in the hypoxic environment of the tumor and expresses CD, an enzyme that catalyzes the intracellular conversion of the prodrug flucytosine (5-FC) into the antineoplastic agent 5-fluorouracil (5-FU). Upon administration of 5-FC, and subsequent localized conversion into 5-FU and its cytotoxic active metabolites, the tumor is specifically exposed to cytotoxic agents while the exposure to normal tissues is minimal." @default.
- NCIT_C101367 NCIT_NHC0 "C101367" @default.
- NCIT_C101367 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101367 NCIT_P107 "CD-expressing Bifidobacterium APS001F" @default.
- NCIT_C101367 NCIT_P108 "CD-expressing Bifidobacterium APS001F" @default.
- NCIT_C101367 NCIT_P208 "CL435547" @default.
- NCIT_C101367 NCIT_P322 "CTRP" @default.
- NCIT_C101367 NCIT_P329 "729923" @default.
- NCIT_C101367 NCIT_P330 "729923" @default.
- NCIT_C101367 NCIT_P399 "729923" @default.
- NCIT_C101367 normalizedInformationContent "100" @default.
- NCIT_C101367 referenceCount "1" @default.
- NCIT_C101367 hasExactSynonym "APS001F" @default.
- NCIT_C101367 hasExactSynonym "CD-expressing Bifidobacterium APS001F" @default.
- NCIT_C101367 inSubset NCIT_C116977 @default.
- NCIT_C101367 inSubset NCIT_C116978 @default.
- NCIT_C101367 inSubset NCIT_C176424 @default.
- NCIT_C101367 type Class @default.
- NCIT_C101367 isDefinedBy ncit.owl @default.
- NCIT_C101367 label "CD-expressing Bifidobacterium APS001F" @default.
- NCIT_C101367 subClassOf NCIT_C101367 @default.
- NCIT_C101367 subClassOf NCIT_C1908 @default.
- NCIT_C101367 subClassOf NCIT_C1909 @default.
- NCIT_C101367 subClassOf NCIT_C26170 @default.