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- NCIT_C101517 IAO_0000115 "An orally available nutritional supplement containing the gamma and delta forms of the vitamin E family member tocotrienol, with hypocholesterolemic, antithrombotic, antioxidant, and potential antineoplastic activity. Upon oral administration, gamma-delta tocotrienol accumulates in cancer cells and may exert their anti-cancer activity in part through 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase downregulation and/or degradation, cell cycle arrest, and induction of caspase-mediated apoptosis. In addition, this agent may inhibit angiogenesis partially through the blockage of vascular endothelial growth factor receptor (VEGFR) and the inhibition of tumor cell-induced vessel formation. Altogether, this may result in the inhibition of tumor cell growth. Further, this agent prevents free radical formation and inhibits lipid peroxidation. Tocotrienols contain 3 double bonds, absent in tocopherols, on its farnesyl isoprenoid side chain that likely contribute to its anti-cancer activities." @default.
- NCIT_C101517 NCIT_A32 NCIT_C1909 @default.
- NCIT_C101517 NCIT_NHC0 "C101517" @default.
- NCIT_C101517 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101517 NCIT_P108 "Gamma-delta Tocotrienol" @default.
- NCIT_C101517 NCIT_P208 "CL435774" @default.
- NCIT_C101517 NCIT_P322 "GDC" @default.
- NCIT_C101517 NCIT_P329 "730661" @default.
- NCIT_C101517 NCIT_P330 "730661" @default.
- NCIT_C101517 NCIT_P375 "Gamma-delta Tocotrienol" @default.
- NCIT_C101517 NCIT_P399 "730661" @default.
- NCIT_C101517 normalizedInformationContent "100" @default.
- NCIT_C101517 referenceCount "1" @default.
- NCIT_C101517 hasExactSynonym "GDT" @default.
- NCIT_C101517 hasExactSynonym "Gamma-delta Tocotrienol" @default.
- NCIT_C101517 hasExactSynonym "gdT3" @default.
- NCIT_C101517 inSubset NCIT_C128784 @default.
- NCIT_C101517 inSubset NCIT_C157711 @default.
- NCIT_C101517 inSubset NCIT_C157712 @default.
- NCIT_C101517 inSubset NCIT_C176424 @default.
- NCIT_C101517 inSubset NCIT_C177537 @default.
- NCIT_C101517 type Class @default.
- NCIT_C101517 isDefinedBy ncit.owl @default.
- NCIT_C101517 label "Gamma-delta Tocotrienol" @default.
- NCIT_C101517 subClassOf NCIT_C101517 @default.
- NCIT_C101517 subClassOf NCIT_C1505 @default.
- NCIT_C101517 subClassOf NCIT_C1908 @default.