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- NCIT_C101519 IAO_0000115 "A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. Edicotinib blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS can not activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tumor cells. FMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation, recruitment, and activation as well as the regulation of cell proliferation." @default.
- NCIT_C101519 NCIT_A32 NCIT_C1909 @default.
- NCIT_C101519 NCIT_A7 NCIT_C17392 @default.
- NCIT_C101519 NCIT_NHC0 "C101519" @default.
- NCIT_C101519 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101519 NCIT_P107 "Edicotinib" @default.
- NCIT_C101519 NCIT_P108 "Edicotinib" @default.
- NCIT_C101519 NCIT_P207 "C3640124" @default.
- NCIT_C101519 NCIT_P210 "1142363-52-7" @default.
- NCIT_C101519 NCIT_P319 "3NU609VYNF" @default.
- NCIT_C101519 NCIT_P322 "CTRP" @default.
- NCIT_C101519 NCIT_P322 "FDA" @default.
- NCIT_C101519 NCIT_P322 "GDC" @default.
- NCIT_C101519 NCIT_P329 "730665" @default.
- NCIT_C101519 NCIT_P330 "730665" @default.
- NCIT_C101519 NCIT_P375 "Edicotinib" @default.
- NCIT_C101519 NCIT_P375 "FMS Inhibitor JNJ-40346527" @default.
- NCIT_C101519 NCIT_P399 "730665" @default.
- NCIT_C101519 NCIT_R124 NCIT_C17828 @default.
- NCIT_C101519 NCIT_R124 NCIT_C18992 @default.
- NCIT_C101519 NCIT_R124 NCIT_C19143 @default.
- NCIT_C101519 NCIT_R124 NCIT_C21124 @default.
- NCIT_C101519 NCIT_R124 NCIT_C40702 @default.
- NCIT_C101519 NCIT_R124 NCIT_C40703 @default.
- NCIT_C101519 NCIT_R124 NCIT_C40704 @default.
- NCIT_C101519 NCIT_R125 NCIT_C17133 @default.
- NCIT_C101519 NCIT_R125 NCIT_C17828 @default.
- NCIT_C101519 NCIT_R125 NCIT_C18081 @default.
- NCIT_C101519 NCIT_R125 NCIT_C20480 @default.
- NCIT_C101519 NCIT_R125 NCIT_C20751 @default.
- NCIT_C101519 NCIT_R125 NCIT_C40821 @default.
- NCIT_C101519 normalizedInformationContent "100" @default.
- NCIT_C101519 referenceCount "1" @default.
- NCIT_C101519 hasExactSynonym "1H-Imidazole-2-carboxamide, 5-Cyano-N-(2-(4,4-dimethyl-1-cyclohexen-1-yl)-6-(tetrahydro-2,2,6,6-tetramethyl-2H-pyran-4-yl)-3-pyridinyl)-" @default.
- NCIT_C101519 hasExactSynonym "4-Cyano-1H-imidazole-2-carboxylic acid N-(2-(4,4-dimethylcyclohex-1-enyl)-6-(2,2,6,6-tetramethyltetrahydropyran-4-yl)pyridin-3-yl)amide" @default.
- NCIT_C101519 hasExactSynonym "4-Cyano-N-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyl-tetrahydro-2H-pyran-4-yl)pyridin-3-yl)-1H-imidazole-2-carboxamide" @default.
- NCIT_C101519 hasExactSynonym "EDICOTINIB" @default.
- NCIT_C101519 hasExactSynonym "Edicotinib" @default.
- NCIT_C101519 hasExactSynonym "JNJ-40346527" @default.
- NCIT_C101519 inSubset NCIT_C116977 @default.
- NCIT_C101519 inSubset NCIT_C116978 @default.
- NCIT_C101519 inSubset NCIT_C128784 @default.
- NCIT_C101519 inSubset NCIT_C157711 @default.
- NCIT_C101519 inSubset NCIT_C157712 @default.
- NCIT_C101519 inSubset NCIT_C176424 @default.
- NCIT_C101519 inSubset NCIT_C177537 @default.
- NCIT_C101519 inSubset NCIT_C63923 @default.
- NCIT_C101519 type Class @default.
- NCIT_C101519 isDefinedBy ncit.owl @default.
- NCIT_C101519 label "Edicotinib" @default.
- NCIT_C101519 subClassOf B399c9055a12dbbaafbda88ade3514cec @default.
- NCIT_C101519 subClassOf B419f83ebbcbad9a646c83731f3fbd8ef @default.
- NCIT_C101519 subClassOf B5438eb36a944a17181110eb6708b0eaf @default.
- NCIT_C101519 subClassOf B7b448a8d8080e8244f587373e2d5d9c4 @default.
- NCIT_C101519 subClassOf B7bb7c088eacfb958ebfee31ea6c43e3f @default.
- NCIT_C101519 subClassOf Be49af4c228d5af6a8279b358b58a94df @default.
- NCIT_C101519 subClassOf NCIT_C101519 @default.
- NCIT_C101519 subClassOf NCIT_C1404 @default.
- NCIT_C101519 subClassOf NCIT_C1908 @default.
- NCIT_C101519 subClassOf NCIT_C1909 @default.
- NCIT_C101519 subClassOf NCIT_C1967 @default.
- NCIT_C101519 subClassOf NCIT_C471 @default.