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- NCIT_C101525 IAO_0000115 "An inhibitor of transient receptor potential cation channel vanilloid family member 6 (TRPV6, CaT1 or CATL) with potential antineoplastic activity. TRPV6 calcium channel inhibitor SOR-C13 binds to TRPV6 and prevents the influx of calcium ions into TRPV6-expressing tumor cells. This inhibits the activation of nuclear factor of activated T-cell (NFAT) transcription complex which may result in an inhibition of calcium-dependent cancer cell proliferation and an induction of apoptosis in tumor cells overexpressing TRPV6. The TRPV6 ion channel plays a key role in calcium homeostasis and is highly selective for calcium compared to other cations; it is overexpressed in a variety of tumors and initiates tumor cell growth, proliferation and metastases." @default.
- NCIT_C101525 NCIT_A32 NCIT_C1909 @default.
- NCIT_C101525 NCIT_NHC0 "C101525" @default.
- NCIT_C101525 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101525 NCIT_P108 "TRPV6 Calcium Channel Inhibitor SOR-C13" @default.
- NCIT_C101525 NCIT_P208 "CL435782" @default.
- NCIT_C101525 NCIT_P210 "1187852-48-7" @default.
- NCIT_C101525 NCIT_P319 "C79B5A73C4" @default.
- NCIT_C101525 NCIT_P322 "FDA" @default.
- NCIT_C101525 NCIT_P322 "GDC" @default.
- NCIT_C101525 NCIT_P329 "732361" @default.
- NCIT_C101525 NCIT_P330 "732361" @default.
- NCIT_C101525 NCIT_P375 "TRPV6 Calcium Channel Inhibitor SOR-C13" @default.
- NCIT_C101525 NCIT_P399 "732361" @default.
- NCIT_C101525 normalizedInformationContent "100" @default.
- NCIT_C101525 referenceCount "1" @default.
- NCIT_C101525 hasExactSynonym "SOR-C13" @default.
- NCIT_C101525 hasExactSynonym "TRPV6 Calcium Channel Inhibitor SOR-C13" @default.
- NCIT_C101525 inSubset NCIT_C128784 @default.
- NCIT_C101525 inSubset NCIT_C157711 @default.
- NCIT_C101525 inSubset NCIT_C157712 @default.
- NCIT_C101525 inSubset NCIT_C176424 @default.
- NCIT_C101525 inSubset NCIT_C177537 @default.
- NCIT_C101525 inSubset NCIT_C63923 @default.
- NCIT_C101525 type Class @default.
- NCIT_C101525 isDefinedBy ncit.owl @default.
- NCIT_C101525 label "TRPV6 Calcium Channel Inhibitor SOR-C13" @default.
- NCIT_C101525 subClassOf NCIT_C101525 @default.
- NCIT_C101525 subClassOf NCIT_C129824 @default.
- NCIT_C101525 subClassOf NCIT_C1908 @default.
- NCIT_C101525 subClassOf NCIT_C1909 @default.
- NCIT_C101525 subClassOf NCIT_C2189 @default.
- NCIT_C101525 subClassOf NCIT_C274 @default.