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- NCIT_C101790 IAO_0000115 "An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, alectinib binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors. The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors." @default.
- NCIT_C101790 NCIT_A32 NCIT_C1909 @default.
- NCIT_C101790 NCIT_A7 NCIT_C27032 @default.
- NCIT_C101790 NCIT_NHC0 "C101790" @default.
- NCIT_C101790 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101790 NCIT_P107 "Alectinib" @default.
- NCIT_C101790 NCIT_P108 "Alectinib" @default.
- NCIT_C101790 NCIT_P207 "C3853921" @default.
- NCIT_C101790 NCIT_P210 "1256580-46-7" @default.
- NCIT_C101790 NCIT_P302 "anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC)" @default.
- NCIT_C101790 NCIT_P319 "LIJ4CT1Z3Y" @default.
- NCIT_C101790 NCIT_P322 "CTRP" @default.
- NCIT_C101790 NCIT_P322 "FDA" @default.
- NCIT_C101790 NCIT_P322 "GDC" @default.
- NCIT_C101790 NCIT_P329 "733572" @default.
- NCIT_C101790 NCIT_P330 "733572" @default.
- NCIT_C101790 NCIT_P368 "CHEBI:62268" @default.
- NCIT_C101790 NCIT_P375 "Alectinib" @default.
- NCIT_C101790 NCIT_P399 "733572" @default.
- NCIT_C101790 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C101790 referenceCount "2" @default.
- NCIT_C101790 hasExactSynonym "5H-benzo(b)carbazole-3-carbonitrile, 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-(4-(4-morpholinyl)-1-piperidinyl)-11-oxo-" @default.
- NCIT_C101790 hasExactSynonym "AF-802" @default.
- NCIT_C101790 hasExactSynonym "AF802" @default.
- NCIT_C101790 hasExactSynonym "ALECTINIB" @default.
- NCIT_C101790 hasExactSynonym "ALK Inhibitor RO5424802" @default.
- NCIT_C101790 hasExactSynonym "Alecensa" @default.
- NCIT_C101790 hasExactSynonym "Alectinib" @default.
- NCIT_C101790 hasExactSynonym "CH5424802" @default.
- NCIT_C101790 hasExactSynonym "RG7853" @default.
- NCIT_C101790 hasExactSynonym "RO5424802" @default.
- NCIT_C101790 inSubset NCIT_C116977 @default.
- NCIT_C101790 inSubset NCIT_C116978 @default.
- NCIT_C101790 inSubset NCIT_C128784 @default.
- NCIT_C101790 inSubset NCIT_C157711 @default.
- NCIT_C101790 inSubset NCIT_C157712 @default.
- NCIT_C101790 inSubset NCIT_C176424 @default.
- NCIT_C101790 inSubset NCIT_C177537 @default.
- NCIT_C101790 inSubset NCIT_C63923 @default.
- NCIT_C101790 type Class @default.
- NCIT_C101790 isDefinedBy ncit.owl @default.
- NCIT_C101790 label "Alectinib" @default.
- NCIT_C101790 subClassOf NCIT_C101790 @default.
- NCIT_C101790 subClassOf NCIT_C129824 @default.
- NCIT_C101790 subClassOf NCIT_C129825 @default.
- NCIT_C101790 subClassOf NCIT_C1404 @default.
- NCIT_C101790 subClassOf NCIT_C141136 @default.
- NCIT_C101790 subClassOf NCIT_C163758 @default.
- NCIT_C101790 subClassOf NCIT_C1908 @default.
- NCIT_C101790 subClassOf NCIT_C1909 @default.
- NCIT_C101790 subClassOf NCIT_C1967 @default.
- NCIT_C101790 subClassOf NCIT_C2189 @default.
- NCIT_C101790 subClassOf NCIT_C274 @default.
- NCIT_C101790 subClassOf NCIT_C471 @default.