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- NCIT_C101792 IAO_0000115 "A formulation of the 6-omega fatty acid derivative 2'-linoleyl carbonate (LOC) conjugated to paclitaxel, a taxane compound extracted from the Pacific yew tree Taxus brevifolia, with potential antineoplastic activity. Paclitaxel binds to and stabilizes tubulin, thereby interfering with the dynamics of microtubule assembly/disassembly and resulting in the inhibition of cell division. LOC enhances the uptake of paclitaxel by tumor cells, thereby concentrating this agent in tumor cells compared to normal cells, and may decrease its toxicity profile; fatty acids serve as energy sources and biochemical precursors for the fast growing tumor cells." @default.
- NCIT_C101792 NCIT_A32 NCIT_C1909 @default.
- NCIT_C101792 NCIT_A7 NCIT_C17219 @default.
- NCIT_C101792 NCIT_NHC0 "C101792" @default.
- NCIT_C101792 NCIT_P106 "Organic Chemical" @default.
- NCIT_C101792 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101792 NCIT_P107 "Linoleyl Carbonate-paclitaxel" @default.
- NCIT_C101792 NCIT_P108 "Linoleyl Carbonate-Paclitaxel" @default.
- NCIT_C101792 NCIT_P208 "CL435910" @default.
- NCIT_C101792 NCIT_P322 "CTRP" @default.
- NCIT_C101792 NCIT_P322 "GDC" @default.
- NCIT_C101792 NCIT_P329 "733643" @default.
- NCIT_C101792 NCIT_P330 "733643" @default.
- NCIT_C101792 NCIT_P375 "Linoleyl Carbonate-Paclitaxel" @default.
- NCIT_C101792 NCIT_P399 "733643" @default.
- NCIT_C101792 NCIT_R124 NCIT_C17828 @default.
- NCIT_C101792 NCIT_R124 NCIT_C20480 @default.
- NCIT_C101792 NCIT_R124 NCIT_C40795 @default.
- NCIT_C101792 NCIT_R124 NCIT_C40798 @default.
- NCIT_C101792 normalizedInformationContent "100" @default.
- NCIT_C101792 referenceCount "1" @default.
- NCIT_C101792 hasExactSynonym "2-Linoleyl Carbonate-paclitaxel" @default.
- NCIT_C101792 hasExactSynonym "LOC-paclitaxel" @default.
- NCIT_C101792 hasExactSynonym "Linoleyl Carbonate-Paclitaxel" @default.
- NCIT_C101792 hasExactSynonym "Linoleyl Carbonate-paclitaxel" @default.
- NCIT_C101792 inSubset NCIT_C116977 @default.
- NCIT_C101792 inSubset NCIT_C116978 @default.
- NCIT_C101792 inSubset NCIT_C128784 @default.
- NCIT_C101792 inSubset NCIT_C157711 @default.
- NCIT_C101792 inSubset NCIT_C157712 @default.
- NCIT_C101792 inSubset NCIT_C176424 @default.
- NCIT_C101792 inSubset NCIT_C177537 @default.
- NCIT_C101792 type Class @default.
- NCIT_C101792 isDefinedBy ncit.owl @default.
- NCIT_C101792 label "Linoleyl Carbonate-Paclitaxel" @default.
- NCIT_C101792 subClassOf NCIT_C101792 @default.
- NCIT_C101792 subClassOf NCIT_C186664 @default.
- NCIT_C101792 subClassOf NCIT_C1908 @default.
- NCIT_C101792 subClassOf NCIT_C1909 @default.
- NCIT_C101792 subClassOf NCIT_C25974 @default.
- NCIT_C101792 subClassOf NCIT_C273 @default.
- NCIT_C101792 subClassOf NCIT_C274 @default.
- NCIT_C101792 subClassOf NCIT_C67437 @default.