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- NCIT_C101795 IAO_0000115 "An orally bioavailable inhibitor of raptor-mTOR protein complex (TORC1) and rictor-mTOR protein complex (TORC2) with potential antineoplastic activity. TORC1/2 inhibitor DS-3078a binds to and inhibits both TORC1 and TORC2, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers." @default.
- NCIT_C101795 NCIT_A32 NCIT_C1909 @default.
- NCIT_C101795 NCIT_NHC0 "C101795" @default.
- NCIT_C101795 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101795 NCIT_P108 "TORC1/2 Kinase Inhibitor DS-3078a" @default.
- NCIT_C101795 NCIT_P208 "CL435913" @default.
- NCIT_C101795 NCIT_P322 "GDC" @default.
- NCIT_C101795 NCIT_P329 "733685" @default.
- NCIT_C101795 NCIT_P330 "733685" @default.
- NCIT_C101795 NCIT_P375 "TORC1/2 Kinase Inhibitor DS-3078a" @default.
- NCIT_C101795 NCIT_P399 "733685" @default.
- NCIT_C101795 normalizedInformationContent "100" @default.
- NCIT_C101795 referenceCount "1" @default.
- NCIT_C101795 hasExactSynonym "DS-3078a" @default.
- NCIT_C101795 hasExactSynonym "TORC1/2 Kinase Inhibitor DS-3078a" @default.
- NCIT_C101795 inSubset NCIT_C128784 @default.
- NCIT_C101795 inSubset NCIT_C157711 @default.
- NCIT_C101795 inSubset NCIT_C157712 @default.
- NCIT_C101795 inSubset NCIT_C176424 @default.
- NCIT_C101795 inSubset NCIT_C177537 @default.
- NCIT_C101795 type Class @default.
- NCIT_C101795 isDefinedBy ncit.owl @default.
- NCIT_C101795 label "TORC1/2 Kinase Inhibitor DS-3078a" @default.
- NCIT_C101795 subClassOf NCIT_C101795 @default.
- NCIT_C101795 subClassOf NCIT_C129824 @default.
- NCIT_C101795 subClassOf NCIT_C129825 @default.
- NCIT_C101795 subClassOf NCIT_C1404 @default.
- NCIT_C101795 subClassOf NCIT_C163758 @default.
- NCIT_C101795 subClassOf NCIT_C1908 @default.
- NCIT_C101795 subClassOf NCIT_C1909 @default.
- NCIT_C101795 subClassOf NCIT_C2189 @default.
- NCIT_C101795 subClassOf NCIT_C2201 @default.
- NCIT_C101795 subClassOf NCIT_C274 @default.
- NCIT_C101795 subClassOf NCIT_C471 @default.
- NCIT_C101795 subClassOf NCIT_C61074 @default.