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- NCIT_C101889 IAO_0000115 "A liposomal formulation consisting of short-interfering RNAs (siRNAs) directed against ephrin type-A receptor 2 (EphA2) and encapsulated into 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) neutral liposomes, with potential antineoplastic activity. Upon internalization, EphA2-targeting DOPC-encapsulated siRNA can hybridize to EphA2 DNA and mRNA, thereby interfering with both the transcription and translation of EphA2, and thus inhibiting tumor cell growth. The cell-surface receptor EphA2, a member of the ephrin family of receptor tyrosine kinases (RTKs) involved in mammalian development, is overexpressed by a variety of different cancer cell types and plays an important role in tumor growth." @default.
- NCIT_C101889 NCIT_A7 NCIT_C26156 @default.
- NCIT_C101889 NCIT_NHC0 "C101889" @default.
- NCIT_C101889 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101889 NCIT_P107 "EphA2-targeting DOPC-encapsulated siRNA" @default.
- NCIT_C101889 NCIT_P108 "EphA2-targeting DOPC-encapsulated siRNA" @default.
- NCIT_C101889 NCIT_P208 "CL436272" @default.
- NCIT_C101889 NCIT_P322 "CTRP" @default.
- NCIT_C101889 NCIT_P329 "733792" @default.
- NCIT_C101889 NCIT_P330 "733792" @default.
- NCIT_C101889 NCIT_P399 "733792" @default.
- NCIT_C101889 normalizedInformationContent "100" @default.
- NCIT_C101889 referenceCount "1" @default.
- NCIT_C101889 hasExactSynonym "EphA2-targeting DOPC-encapsulated siRNA" @default.
- NCIT_C101889 hasExactSynonym "siRNA-EphA2-DOPC" @default.
- NCIT_C101889 inSubset NCIT_C116977 @default.
- NCIT_C101889 inSubset NCIT_C116978 @default.
- NCIT_C101889 inSubset NCIT_C128784 @default.
- NCIT_C101889 inSubset NCIT_C176424 @default.
- NCIT_C101889 type Class @default.
- NCIT_C101889 isDefinedBy ncit.owl @default.
- NCIT_C101889 label "EphA2-targeting DOPC-encapsulated siRNA" @default.
- NCIT_C101889 subClassOf NCIT_C101889 @default.
- NCIT_C101889 subClassOf NCIT_C129821 @default.
- NCIT_C101889 subClassOf NCIT_C1908 @default.
- NCIT_C101889 subClassOf NCIT_C1909 @default.
- NCIT_C101889 subClassOf NCIT_C274 @default.
- NCIT_C101889 subClassOf NCIT_C307 @default.