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- NCIT_C101894 IAO_0000115 "A polybisphosphonate dextran-guanidine conjugate with potential anti-resorptive and antineoplastic activities. Alendronic acid and aminoguanidine were conjugated sequentially to oxidized dextran resulting in an average of 8 alendronate and 50 guanidine groups coupled to the dextran backbone. Upon administration, the poly-alendronate dextran-guanidine conjugate inhibits the mevalonate pathway by inhibiting farnesyl diphosphate synthase (FDPS) which leads to a reduction in protein prenylation and to the loss of downstream metabolites essential for osteoclast function. This eventually leads to the induction of apoptosis in osteoclasts. Also, by preventing osteoclast-mediated bone resorption, this agent decreases bone turnover and stabilizes the bone matrix. The guanidine moiety increases the nitrogen content and possibly the activity of the bisphosphonate and its ability to inhibit FDPS. In addition, the guanidine moiety facilitates cell internalization and may contribute to this agent's cytotoxicity." @default.
- NCIT_C101894 NCIT_A32 NCIT_C1909 @default.
- NCIT_C101894 NCIT_NHC0 "C101894" @default.
- NCIT_C101894 NCIT_P106 "Organic Chemical" @default.
- NCIT_C101894 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101894 NCIT_P108 "Poly-alendronate Dextran-Guanidine Conjugate" @default.
- NCIT_C101894 NCIT_P208 "CL436277" @default.
- NCIT_C101894 NCIT_P322 "GDC" @default.
- NCIT_C101894 NCIT_P329 "733915" @default.
- NCIT_C101894 NCIT_P330 "733915" @default.
- NCIT_C101894 NCIT_P375 "Poly-alendronate Dextran-Guanidine Conjugate" @default.
- NCIT_C101894 NCIT_P399 "733915" @default.
- NCIT_C101894 normalizedInformationContent "100" @default.
- NCIT_C101894 referenceCount "1" @default.
- NCIT_C101894 hasExactSynonym "Dextran/Alendronate/Guanidine-containing Polybisphosphonate" @default.
- NCIT_C101894 hasExactSynonym "ODX" @default.
- NCIT_C101894 hasExactSynonym "Osteodex" @default.
- NCIT_C101894 hasExactSynonym "Poly-alendronate Dextran-Guanidine Conjugate" @default.
- NCIT_C101894 inSubset NCIT_C128784 @default.
- NCIT_C101894 inSubset NCIT_C157711 @default.
- NCIT_C101894 inSubset NCIT_C157712 @default.
- NCIT_C101894 inSubset NCIT_C176424 @default.
- NCIT_C101894 inSubset NCIT_C177537 @default.
- NCIT_C101894 type Class @default.
- NCIT_C101894 isDefinedBy ncit.owl @default.
- NCIT_C101894 label "Poly-alendronate Dextran-Guanidine Conjugate" @default.
- NCIT_C101894 subClassOf NCIT_C101894 @default.
- NCIT_C101894 subClassOf NCIT_C1908 @default.
- NCIT_C101894 subClassOf NCIT_C1909 @default.
- NCIT_C101894 subClassOf NCIT_C1913 @default.
- NCIT_C101894 subClassOf NCIT_C443 @default.
- NCIT_C101894 subClassOf NCIT_C67439 @default.
- NCIT_C101894 subClassOf NCIT_C718 @default.
- NCIT_C101894 subClassOf NCIT_C78281 @default.