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- NCIT_C102545 IAO_0000115 "A recombinant, replicating oncolytic vesicular stomatitis virus (VSV) carrying the human interferon-beta (IFN-b) gene, with potential immunomodulating and antineoplastic activities. Upon intratumoral administration, recombinant VSV expressing IFN-b replicates in the tumor environment specifically, partially due to defective innate antiviral host defense mechanisms in tumor cells, involving type I IFNs, and exerts its cytolytic activity towards the tumor cells. By expressing human IFN-b, an INF-b-mediated antiviral immune response in surrounding normal cells is activated which protects normal cells against virus replication and VSV-mediated cell lysis. However, tumor cells have a defective IFN-b-mediated innate antiviral immune response allowing for VSV to replicate in these cells without interference. In addition, the IFN-b produced by VSV may activate an immune response in surrounding normal cells and may activate T-lymphocytes, dendritic cells and natural killer cells; thus, inducing an anti-tumor immune response against the tumor cells. VSV, a single-stranded RNA virus belonging to the genus Vesiculovirus of the family Rhabdoviridae, is relatively nonpathogenic to healthy humans." @default.
- NCIT_C102545 NCIT_NHC0 "C102545" @default.
- NCIT_C102545 NCIT_P106 "Virus" @default.
- NCIT_C102545 NCIT_P107 "Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta" @default.
- NCIT_C102545 NCIT_P108 "Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta" @default.
- NCIT_C102545 NCIT_P208 "CL436814" @default.
- NCIT_C102545 NCIT_P322 "CTRP" @default.
- NCIT_C102545 NCIT_P329 "734527" @default.
- NCIT_C102545 NCIT_P330 "734527" @default.
- NCIT_C102545 NCIT_P399 "734527" @default.
- NCIT_C102545 normalizedInformationContent "100" @default.
- NCIT_C102545 referenceCount "1" @default.
- NCIT_C102545 hasExactSynonym "Recombinant VSV-IFN-beta" @default.
- NCIT_C102545 hasExactSynonym "Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta" @default.
- NCIT_C102545 hasExactSynonym "VSV-hIFN-b" @default.
- NCIT_C102545 inSubset NCIT_C116977 @default.
- NCIT_C102545 inSubset NCIT_C116978 @default.
- NCIT_C102545 inSubset NCIT_C128784 @default.
- NCIT_C102545 inSubset NCIT_C176424 @default.
- NCIT_C102545 type Class @default.
- NCIT_C102545 isDefinedBy ncit.owl @default.
- NCIT_C102545 label "Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta" @default.
- NCIT_C102545 subClassOf NCIT_C102545 @default.
- NCIT_C102545 subClassOf NCIT_C129821 @default.
- NCIT_C102545 subClassOf NCIT_C1908 @default.
- NCIT_C102545 subClassOf NCIT_C1909 @default.
- NCIT_C102545 subClassOf NCIT_C274 @default.
- NCIT_C102545 subClassOf NCIT_C307 @default.
- NCIT_C102545 subClassOf NCIT_C717 @default.