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- NCIT_C102547 IAO_0000115 "A nutritional supplement containing the active metabolite of the essential amino acid leucine, with potential anti-catabolic and anabolic activities. Upon oral administration of beta-hydroxy-beta-methylbutyrate (HMB), this leucine metabolite may decrease protein breakdown and increase protein synthesis thereby increasing muscle strength and mass. Although the exact mechanisms remain to be fully elucidated, multiple mechanisms have been proposed: 1) HMB is a precursor of cholesterol synthesis in skeletal muscle cells thereby increasing sarcolemmal integrity; 2) HMB may inhibit the ubiquitin-proteasome proteolytic pathway responsible for the specific degradation of intracellular proteins, thereby preventing muscular proteolysis; and/or 3) HMB may stimulate protein synthesis through a mammalian target of rapamycin (mTOR)-mediated mechanism." @default.
- NCIT_C102547 NCIT_NHC0 "C102547" @default.
- NCIT_C102547 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102547 NCIT_P108 "Beta-hydroxy-beta-methylbutyrate Supplement" @default.
- NCIT_C102547 NCIT_P208 "CL436816" @default.
- NCIT_C102547 NCIT_P329 "734830" @default.
- NCIT_C102547 NCIT_P330 "734830" @default.
- NCIT_C102547 NCIT_P399 "734830" @default.
- NCIT_C102547 normalizedInformationContent "100" @default.
- NCIT_C102547 referenceCount "1" @default.
- NCIT_C102547 hasExactSynonym "Beta-hydroxy-beta-methylbutyrate Supplement" @default.
- NCIT_C102547 hasExactSynonym "HMB Supplement" @default.
- NCIT_C102547 inSubset NCIT_C176424 @default.
- NCIT_C102547 type Class @default.
- NCIT_C102547 isDefinedBy ncit.owl @default.
- NCIT_C102547 label "Beta-hydroxy-beta-methylbutyrate Supplement" @default.
- NCIT_C102547 subClassOf NCIT_C102547 @default.
- NCIT_C102547 subClassOf NCIT_C1505 @default.
- NCIT_C102547 subClassOf NCIT_C1908 @default.