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- NCIT_C102565 IAO_0000115 "A proprietary fusion protein comprised of the cysteine-rich domain of frizzled family receptor 8 (Fzd8) fused to the human immunoglobulin Fc domain with potential antineoplastic activity. Upon intravenous administration, ipafricept competes with the membrane-bound Fzd8 receptor for its ligand, Wnt proteins, thereby antagonizing Wnt signaling. This may result in the inhibition of Wnt-driven tumor growth. Fzd8, a member of the Frizzled family of G protein-coupled receptors, is one of the components in the Wnt/beta-catenin signaling pathway that plays key roles in embryogenesis and cancer growth." @default.
- NCIT_C102565 NCIT_A32 NCIT_C1909 @default.
- NCIT_C102565 NCIT_NHC0 "C102565" @default.
- NCIT_C102565 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102565 NCIT_P107 "Ipafricept" @default.
- NCIT_C102565 NCIT_P108 "Ipafricept" @default.
- NCIT_C102565 NCIT_P171 "17545618" @default.
- NCIT_C102565 NCIT_P207 "C4049114" @default.
- NCIT_C102565 NCIT_P210 "1391727-24-4" @default.
- NCIT_C102565 NCIT_P319 "2N71QUE3NL" @default.
- NCIT_C102565 NCIT_P322 "CTRP" @default.
- NCIT_C102565 NCIT_P322 "FDA" @default.
- NCIT_C102565 NCIT_P322 "GDC" @default.
- NCIT_C102565 NCIT_P329 "734935" @default.
- NCIT_C102565 NCIT_P330 "734935" @default.
- NCIT_C102565 NCIT_P375 "Ipafricept" @default.
- NCIT_C102565 NCIT_P399 "734935" @default.
- NCIT_C102565 normalizedInformationContent "100" @default.
- NCIT_C102565 referenceCount "1" @default.
- NCIT_C102565 hasExactSynonym "Fusion Protein For Immune Applications (fpia) Comprising Homo Sapiens FZD8 (Frizzled Family Receptor 8, Frizzled-8) Extracellular Domain, Fused With Homo Sapiens Immunoglobulin G1 Fc Fragment" @default.
- NCIT_C102565 hasExactSynonym "Fzd8-Fc" @default.
- NCIT_C102565 hasExactSynonym "IPAFRICEPT" @default.
- NCIT_C102565 hasExactSynonym "Ipafricept" @default.
- NCIT_C102565 hasExactSynonym "OMP 54F28" @default.
- NCIT_C102565 hasExactSynonym "OMP-54F28" @default.
- NCIT_C102565 inSubset NCIT_C116977 @default.
- NCIT_C102565 inSubset NCIT_C116978 @default.
- NCIT_C102565 inSubset NCIT_C128784 @default.
- NCIT_C102565 inSubset NCIT_C157711 @default.
- NCIT_C102565 inSubset NCIT_C157712 @default.
- NCIT_C102565 inSubset NCIT_C176424 @default.
- NCIT_C102565 inSubset NCIT_C177537 @default.
- NCIT_C102565 inSubset NCIT_C63923 @default.
- NCIT_C102565 type Class @default.
- NCIT_C102565 isDefinedBy ncit.owl @default.
- NCIT_C102565 label "Ipafricept" @default.
- NCIT_C102565 subClassOf NCIT_C102565 @default.
- NCIT_C102565 subClassOf NCIT_C1512 @default.
- NCIT_C102565 subClassOf NCIT_C1908 @default.
- NCIT_C102565 subClassOf NCIT_C1909 @default.
- NCIT_C102565 subClassOf NCIT_C307 @default.
- NCIT_C102565 subClassOf NCIT_C308 @default.