Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C102569> ?p ?o ?g. }
Showing items 1 to 32 of
32
with 100 items per page.
- NCIT_C102569 IAO_0000115 "A recombinant fusion protein composed of the full-length extracellular domain (soluble) of human receptor tyrosine kinase ephrin type-B receptor 4 (sEphB4) and fused, at its C-terminus, to full-length human serum albumin (HSA), with potential antineoplastic and anti-angiogenic activities. sEphB4-HSA functions as a decoy receptor for the membrane-bound ligand Ephrin-B2 (Efnb2) and interferes with the binding of Efnb2 to its native receptors, including EphB4 and EphA3. This may result in a reduction of angiogenesis and a reduction in cell growth of Efnb2 and/or EphB4 over-expressing tumor cells. In addition, this agent also prevents the angiogenic effects of numerous growth factors due to interactions between Efnb2 and EphB4. Efnb2 and EphB4 are overexpressed in a variety of tumor cell types; the bi-directional signaling of Efnb2-EphB4 plays an important role in angiogenesis and tumor cell migration, invasion, and proliferation. Albumin reduces this agent's degradation, improves circulation time and may thus improve efficacy." @default.
- NCIT_C102569 NCIT_A7 NCIT_C105843 @default.
- NCIT_C102569 NCIT_A7 NCIT_C113832 @default.
- NCIT_C102569 NCIT_NHC0 "C102569" @default.
- NCIT_C102569 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102569 NCIT_P107 "Recombinant EphB4-HSA Fusion Protein" @default.
- NCIT_C102569 NCIT_P108 "Recombinant EphB4-HSA Fusion Protein" @default.
- NCIT_C102569 NCIT_P208 "CL436876" @default.
- NCIT_C102569 NCIT_P319 "SO0RV2V6EJ" @default.
- NCIT_C102569 NCIT_P322 "CTRP" @default.
- NCIT_C102569 NCIT_P322 "FDA" @default.
- NCIT_C102569 NCIT_P329 "735271" @default.
- NCIT_C102569 NCIT_P330 "735271" @default.
- NCIT_C102569 NCIT_P399 "735271" @default.
- NCIT_C102569 normalizedInformationContent "100" @default.
- NCIT_C102569 referenceCount "1" @default.
- NCIT_C102569 hasExactSynonym "Recombinant EphB4-HSA Fusion Protein" @default.
- NCIT_C102569 hasExactSynonym "SEPHB4-HSA" @default.
- NCIT_C102569 hasExactSynonym "sEphB4-HSA" @default.
- NCIT_C102569 inSubset NCIT_C116977 @default.
- NCIT_C102569 inSubset NCIT_C116978 @default.
- NCIT_C102569 inSubset NCIT_C128784 @default.
- NCIT_C102569 inSubset NCIT_C176424 @default.
- NCIT_C102569 inSubset NCIT_C63923 @default.
- NCIT_C102569 type Class @default.
- NCIT_C102569 isDefinedBy ncit.owl @default.
- NCIT_C102569 label "Recombinant EphB4-HSA Fusion Protein" @default.
- NCIT_C102569 subClassOf NCIT_C102569 @default.
- NCIT_C102569 subClassOf NCIT_C1742 @default.
- NCIT_C102569 subClassOf NCIT_C1908 @default.
- NCIT_C102569 subClassOf NCIT_C1909 @default.
- NCIT_C102569 subClassOf NCIT_C274 @default.