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- NCIT_C1027 IAO_0000115 "A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon administration, budesonide binds to intracellular glucocorticoid receptors (GRs) and induces the expression of glucocorticoid-responsive genes that encode for anti-inflammatory mediators, such as certain anti-inflammatory cytokines, including interleukin 10 (IL-10), and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, budesonide prevents the release of pro-inflammatory cytokines from epithelial cells and macrophages, including interleukin 6 (IL-6), IL-8, interferon-beta (IFNb), and inhibits nuclear factor kappa-B (NF-kB) activation thereby decreasing NF-kB-mediated inflammation." @default.
- NCIT_C1027 NCIT_A7 NCIT_C17071 @default.
- NCIT_C1027 NCIT_NHC0 "C1027" @default.
- NCIT_C1027 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1027 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1027 NCIT_P107 "Budesonide" @default.
- NCIT_C1027 NCIT_P108 "Budesonide" @default.
- NCIT_C1027 NCIT_P207 "C0054201" @default.
- NCIT_C1027 NCIT_P210 "51333-22-3" @default.
- NCIT_C1027 NCIT_P319 "Q3OKS62Q6X" @default.
- NCIT_C1027 NCIT_P322 "CTRP" @default.
- NCIT_C1027 NCIT_P322 "FDA" @default.
- NCIT_C1027 NCIT_P325 "A drug used in the treatment of asthma and rhinitis. It is also being studied in the treatment of cancer. Budesonide belongs to the family of drugs called steroids." @default.
- NCIT_C1027 NCIT_P366 "Budesonide" @default.
- NCIT_C1027 NCIT_P368 "CHEBI:3207" @default.
- NCIT_C1027 NCIT_R122 NCIT_C16484 @default.
- NCIT_C1027 NCIT_R122 NCIT_C16486 @default.
- NCIT_C1027 NCIT_R122 NCIT_C16554 @default.
- NCIT_C1027 NCIT_R122 NCIT_C16865 @default.
- NCIT_C1027 NCIT_R122 NCIT_C16946 @default.
- NCIT_C1027 NCIT_R122 NCIT_C17021 @default.
- NCIT_C1027 NCIT_R122 NCIT_C17573 @default.
- NCIT_C1027 NCIT_R122 NCIT_C20027 @default.
- NCIT_C1027 NCIT_R122 NCIT_C26548 @default.
- NCIT_C1027 NCIT_R122 NCIT_C28459 @default.
- NCIT_C1027 normalizedInformationContent "100" @default.
- NCIT_C1027 referenceCount "1" @default.
- NCIT_C1027 hasExactSynonym "(RS)-11beta,16alpha,17,21,-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal w/ Butyraldehyde" @default.
- NCIT_C1027 hasExactSynonym "BUDESONIDE" @default.
- NCIT_C1027 hasExactSynonym "Budecort" @default.
- NCIT_C1027 hasExactSynonym "Budesonide" @default.
- NCIT_C1027 hasExactSynonym "Butacort" @default.
- NCIT_C1027 hasExactSynonym "Eltair" @default.
- NCIT_C1027 hasExactSynonym "Nasocort" @default.
- NCIT_C1027 hasExactSynonym "Preferid" @default.
- NCIT_C1027 hasExactSynonym "Pregna-1,4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11beta,16alpha)-" @default.
- NCIT_C1027 hasExactSynonym "Pulmicort Turbuhaler" @default.
- NCIT_C1027 hasExactSynonym "Pulmicort" @default.
- NCIT_C1027 hasExactSynonym "Rhinocort" @default.
- NCIT_C1027 hasExactSynonym "budesonide" @default.
- NCIT_C1027 inSubset NCIT_C116977 @default.
- NCIT_C1027 inSubset NCIT_C116978 @default.
- NCIT_C1027 inSubset NCIT_C173381 @default.
- NCIT_C1027 inSubset NCIT_C173383 @default.
- NCIT_C1027 inSubset NCIT_C63923 @default.
- NCIT_C1027 type Class @default.
- NCIT_C1027 isDefinedBy ncit.owl @default.
- NCIT_C1027 label "Budesonide" @default.
- NCIT_C1027 subClassOf NCIT_C1027 @default.
- NCIT_C1027 subClassOf NCIT_C147908 @default.
- NCIT_C1027 subClassOf NCIT_C1636 @default.
- NCIT_C1027 subClassOf NCIT_C1908 @default.
- NCIT_C1027 subClassOf NCIT_C1909 @default.
- NCIT_C1027 subClassOf NCIT_C211 @default.
- NCIT_C1027 subClassOf NCIT_C2364 @default.
- NCIT_C1027 subClassOf NCIT_C308 @default.
- NCIT_C1027 subClassOf NCIT_C521 @default.
- NCIT_C1027 subClassOf NCIT_C548 @default.
- NCIT_C1027 subClassOf NCIT_C574 @default.