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- NCIT_C102745 IAO_0000115 "An extended release (ER) injectable formulation composed of the hydrochloride salt form of bupivacaine, an amide-type, long-acting local anesthetic, in a resorbable sucrose acetate isobutyrate-based matrix, with analgesic activity. Following administration in or around a specific site, ER bupivacaine is released from the matrix over an extended period of time. Upon release, bupivacaine reversibly binds to specific voltage-gated sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions, membrane destabilization, and depolarization inhibition thus disrupting nerve impulse conduction. This eventually leads to a reversible loss of sensation. This formulation may provide pain relief up to 72 hours." @default.
- NCIT_C102745 NCIT_NHC0 "C102745" @default.
- NCIT_C102745 NCIT_P106 "Organic Chemical" @default.
- NCIT_C102745 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102745 NCIT_P107 "Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation" @default.
- NCIT_C102745 NCIT_P108 "Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation" @default.
- NCIT_C102745 NCIT_P208 "CL437002" @default.
- NCIT_C102745 NCIT_P322 "CTRP" @default.
- NCIT_C102745 NCIT_P329 "735755" @default.
- NCIT_C102745 NCIT_P330 "735755" @default.
- NCIT_C102745 NCIT_P399 "735755" @default.
- NCIT_C102745 normalizedInformationContent "100" @default.
- NCIT_C102745 referenceCount "1" @default.
- NCIT_C102745 hasExactSynonym "ER Bupivacaine HCl" @default.
- NCIT_C102745 hasExactSynonym "Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation" @default.
- NCIT_C102745 hasExactSynonym "SABER-Bupivacaine Hydrochloride" @default.
- NCIT_C102745 hasExactSynonym "Sustained Release Bupivacaine Hydrochloride" @default.
- NCIT_C102745 inSubset NCIT_C116977 @default.
- NCIT_C102745 inSubset NCIT_C116978 @default.
- NCIT_C102745 inSubset NCIT_C176424 @default.
- NCIT_C102745 type Class @default.
- NCIT_C102745 isDefinedBy ncit.owl @default.
- NCIT_C102745 label "Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation" @default.
- NCIT_C102745 subClassOf NCIT_C102745 @default.
- NCIT_C102745 subClassOf NCIT_C1908 @default.
- NCIT_C102745 subClassOf NCIT_C1909 @default.
- NCIT_C102745 subClassOf NCIT_C245 @default.
- NCIT_C102745 subClassOf NCIT_C78272 @default.