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- NCIT_C102746 IAO_0000115 "An orally available small molecule inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes genomic instability eventually leading to apoptosis. PARP 1/2 inhibitor E7449 may enhance the cytotoxicity of DNA-damaging agents and of radiotherapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA." @default.
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- NCIT_C102746 NCIT_NHC0 "C102746" @default.
- NCIT_C102746 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102746 NCIT_P107 "PARP/Tankyrase Inhibitor 2X-121" @default.
- NCIT_C102746 NCIT_P108 "PARP/Tankyrase Inhibitor 2X-121" @default.
- NCIT_C102746 NCIT_P208 "CL601883" @default.
- NCIT_C102746 NCIT_P210 "1140964-99-3" @default.
- NCIT_C102746 NCIT_P319 "9X5A2QIA7C" @default.
- NCIT_C102746 NCIT_P322 "CTRP" @default.
- NCIT_C102746 NCIT_P322 "FDA" @default.
- NCIT_C102746 NCIT_P322 "GDC" @default.
- NCIT_C102746 NCIT_P329 "735791" @default.
- NCIT_C102746 NCIT_P330 "735791" @default.
- NCIT_C102746 NCIT_P375 "PARP/Tankyrase Inhibitor 2X-121" @default.
- NCIT_C102746 NCIT_P399 "735791" @default.
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- NCIT_C102746 normalizedInformationContent "100" @default.
- NCIT_C102746 referenceCount "1" @default.
- NCIT_C102746 hasExactSynonym "2X-121" @default.
- NCIT_C102746 hasExactSynonym "E-7449" @default.
- NCIT_C102746 hasExactSynonym "E7449" @default.
- NCIT_C102746 hasExactSynonym "PARP/TNKS Inhibitor 2X-121" @default.
- NCIT_C102746 hasExactSynonym "PARP/Tankyrase Inhibitor 2X-121" @default.
- NCIT_C102746 inSubset NCIT_C116977 @default.
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- NCIT_C102746 inSubset NCIT_C63923 @default.
- NCIT_C102746 type Class @default.
- NCIT_C102746 isDefinedBy ncit.owl @default.
- NCIT_C102746 label "PARP/Tankyrase Inhibitor 2X-121" @default.
- NCIT_C102746 subClassOf NCIT_C102746 @default.
- NCIT_C102746 subClassOf NCIT_C163758 @default.
- NCIT_C102746 subClassOf NCIT_C1908 @default.
- NCIT_C102746 subClassOf NCIT_C1909 @default.
- NCIT_C102746 subClassOf NCIT_C274 @default.
- NCIT_C102746 subClassOf NCIT_C471 @default.
- NCIT_C102746 subClassOf NCIT_C62554 @default.