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- NCIT_C102757 IAO_0000115 "Allodepleted haploidentical T-lymphocytes transduced with the Gal-V pseudotyped retrovirus vector encoding SFG.iCasp9-2A-deltaCD19, with potential immune reconstitution property. SFG.iCasp9-2A-deltaCD19 contains the suicide gene inducible caspase 9 (iCasp9) linked with a 2A-like cleavable peptide to the selectable marker, truncated human CD19 (deltaCD19). iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9 using a short linker (SGGGS). Donor T cell therapy may help control transplant-related viral infections following allogeneic hematopoietic stem cell transplantation. However, even the addition of allodepleted donor T cells can lead to graft-versus-host disease (GVHD). In the event that GVHD begins to develop, the chemical homodimerizer AP1903 can be administered, which binds to the FKBP12-F36V domain activating caspase 9. This results in the death of T cells causing GVHD while sparing the virus reactive T-cells." @default.
- NCIT_C102757 NCIT_NHC0 "C102757" @default.
- NCIT_C102757 NCIT_P106 "Organic Chemical" @default.
- NCIT_C102757 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102757 NCIT_P107 "Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9" @default.
- NCIT_C102757 NCIT_P108 "Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9" @default.
- NCIT_C102757 NCIT_P208 "CL437012" @default.
- NCIT_C102757 NCIT_P322 "CTRP" @default.
- NCIT_C102757 NCIT_P329 "736015" @default.
- NCIT_C102757 NCIT_P330 "736015" @default.
- NCIT_C102757 NCIT_P399 "736015" @default.
- NCIT_C102757 normalizedInformationContent "100" @default.
- NCIT_C102757 referenceCount "1" @default.
- NCIT_C102757 hasExactSynonym "Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9" @default.
- NCIT_C102757 hasExactSynonym "iCasp9 Allogeneic T Cells" @default.
- NCIT_C102757 inSubset NCIT_C116977 @default.
- NCIT_C102757 inSubset NCIT_C116978 @default.
- NCIT_C102757 inSubset NCIT_C176424 @default.
- NCIT_C102757 type Class @default.
- NCIT_C102757 isDefinedBy ncit.owl @default.
- NCIT_C102757 label "Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9" @default.
- NCIT_C102757 subClassOf NCIT_C102757 @default.
- NCIT_C102757 subClassOf NCIT_C142078 @default.
- NCIT_C102757 subClassOf NCIT_C154231 @default.
- NCIT_C102757 subClassOf NCIT_C1908 @default.
- NCIT_C102757 subClassOf NCIT_C1909 @default.
- NCIT_C102757 subClassOf NCIT_C1962 @default.
- NCIT_C102757 subClassOf NCIT_C307 @default.
- NCIT_C102757 subClassOf NCIT_C308 @default.